557 results
Primary objectives- To investigate CSF autoantibodies (NMDAR, AMPAR, VGKC, and GABA receptors) in patients with a psychotic disorder and healthy controls. - To compare levels of immune parameters between patients with a psychotic disorder and…
The aim of this study is to investigate how many patients with an early and/or chronic psychotic disorder reach personal recovery during follow-up and which determinants and processes influence personal, clinical, functional and societal recovery…
Objectives: Primary objective: - To investigate whether high-resolution glutamate levels in the brain of patients that experienced a psychosis differ from healthy individuals.Secondary objectives:- To compare the high resolution glutamate…
The main objective of this study is whether EMDR is an appropriate treatment for women with PTSD after a previous birth. The resulting hypotheses are that at the two follow-up meaurements, in relation to the pretreatment-measurement 1) WITHIN the…
The aim of the current study is to investigate obsessive-compulsive symptoms and executive functioning in ED, BDD, OCD and ASD. Symptoms of ED, BDD, OCD and ASD will be assessed in all four disorders, as well as executive functioning. We hypothesize…
To conduct a pilot study on the relationship between measured sensitivity to reward and the effectiveness of a routine cognitive-behavioral intervention in ADHD. To pilot relevant measurements and generate hypotheses for a larger study in the future…
The primary objective is to investigate if there is a difference in the performance on tasks measuring visual perception and attention between visual hallucinating schizophrenic patients, schizophrenic patients who do not hallucinate and healthy…
The purpose of this study is to study the acquisition and extinction/counterconditioning of aversively conditioned sexual responses. The study will investigate how sexual stimuli may lose sexually rewarding properties by repeated pairing with…
First, to compare MLP children with FT and with EP peers regarding intelligence at age 14 to 15 years. Second, to compare MLP children with FT and with EP peers regarding health, health-related behaviors, growth measures, blood pressure, pubertal…
The primary objective is to determine whether there is a difference in intracortical inhibition and cortical plasticity between MDD patients and unaffected controls.
Main objectieve of this study is if EMDR is an effective treatment for women with FoC. Our hypotheses are that in follow-up measurement compared to the pretreatment-measurement 1) WITHIN the treatment group there will be a decrease in the severity…
The main objective of this (pilot) study is to investigate the role of glutamate in cognitive functioning in adults with 22q11DS using a glutamatergic challenge (riluzole )and high-field MRS. We will relate glutamate concentrations in the striatum…
The aim of this project is to determine the value of a dynamic network approach to predict illness course and outcome of early psychotic symptoms.
To examine whether there is a systematic presence of EWS and change in daily life experiences preceding transitions towards improvement of depressive symptoms within single individuals who receive psychological treatment
The primary aim of this study is to investigate if prophylactic pharmacotherapy peripartum is associated with a lower chance of relapse peripartum. In more detail, we will investigate if there is a difference in relapse between patients that used…
We select patients that have a diagnosed anxiety disorder and are already enrolled to start an intensive exposure therapy program at Pro Persona/Overwaal. In an fMRI session their individual underlying neural mechanism (biomarker) associated with…
The current project aims (1) to unravel underlying mechanisms for the insomnia subtype that has a high risk to convert to depression by evaluating their profile of psychological traits, health history, life events, behavioral habits, environmental…
Our primary objective is to compare children with FXS with children with non-syndromic ASD, a developmental delay (DD) and typically developing (TD) children on three domains: ASD severity, cognitive abilities and (neuro)biological characteristics.…
Primary aim: to confirm that treatment with bumetanide improves daily life functioning and reduces behavioral symptoms related to hyperexcitability in children and adolescents with TSC.Secondary aim: to identify neurophysiological and cognitive…
A unique and cutting-edge 7T imaging study to unravel subregional perturbations in structure and functional connectivity of deep-lying subcortical systems relevant to MDD pathophysiology.