20 results
To investigate whether peak melatonin level and daily secretion patterns differ between delirious and non-delirious older persons admitted to the ICU. To determine factors that potentially influence the association between delirium and melatonin…
The research objective is to investigate the sensitivity, specificity, and predictive values of the delirium monitor based on 4 standardized EEG electrodes who record brain activity.
The overall objective of this study is to identify valid biomarkers for POD/POCD.
Primary objective(s):To evaluate the effect of early haloperidol prophylaxis on the incidence, severity and duration of in-hospital delirium in at-risk patients aged 70 years and over who are acutely admitted to the hospital through the ED, for…
To assess the potential of a short neuropsychological test measuring attentional variability and vigilance preoperatively in predicting postoperative delirium among elderly non-dementia patients undergoing elective surgery.
To assess in vivo microglial activation (as a validated marker of neuroinflammation) using PET-CT and associated neuropsychological characteristics in patients recovered from sepsis associated delirium.
To investigate whether the Actiwatch® actigraph and the Everon* sensor can be helpful in the early diagnosis of a delirium. If both are able to do so, we evaluate which of the two performs best as a delirium screening device.
Objective: In this pilot study experience will be obtained in the simultaneous use of PSG, melatonin assay, CBT-measurement and assessment in ICU patients.
To study the relationship between (a) abnormal concentrations of plasma amino-acids, pterins, HVA and inflammatory parameters and (b) the severity, duration and outcome of delirium. To find a biochemical profile that predicts the occurrence of a…
To examine how sensitive certain (combinations of) EEG parameters are for diagnosing delirium in a heterogeneous group of ICU patients during 24 hours of EEG registration. The delirium assessment by delirium experts will determine which patients…
To determine the differences in EEG properties between delirious and non-delirious (ICU) cardiothoracic surgery patients surgery and to determine the EEG deviation where the largest differences appear. Secondary objective is to determine the…
The primary objective of this study is to test both the CAM-ICU and the ICSDS, using the DSM-IV criteria for delirium as golden standard. A secundary objective is to assess the value of the impression of the ICU physican whether or not a patient is…
The main aims of the proposed study were (1) to determine the effect of delirium on cognitive-, psychological-, functional-, and health outcomes at discharge, 3, 6 and 12 month follow-up. Patients with a delirium at admission will be compared with…
Our objective is to validate multiple diagnostic instruments, especially the pCAM-ICU. By comparing these instruments, we can develope an algoritm which can be used by nursing staff to diagnose the pediatric delirium as soon as possible so that…
Primary questions: 1) Is there a significant difference between the postoperative levels of 6-sulfatoxymelatonin (6-SMT, metabolite of melatonine) in 24 hour urine samples, in elderly patients with traumatic hip fractures, with and without a…
Primary Objective: the relation between the occurrence of CSA-AKI and the duration of peri-operative low mitoPO2 measurements (<20 mmHg). Secondary Objective:- To study the relationship between the occurrence of postoperative cognitive…
To compare the effects of a preoperative PA program in addition to usual care versus usual care only on the change in SB from baseline (T0) to the end of the preoperative (intervention) period (T1) in patients with TAD.
This randomized controlled trial aims to study the effect of implementation of EEG based encephalopathy detection (DeltaScan, Prolira, Utrecht, The Netherlands, hereafter: DeltaScan) on relevant clinical endpoints (ICU length of stay) as well as the…
1. The predictive value of the BAMCOG for developing postoperative delirium/postoperative acute encephalopathy in patients who underwent AVR surgery2. Concurrent validation of the BAMCOG with the MoCA3. The relation between cortisol levels in blood…
Detection of delirium superimposed on pre-existing cognitive impairment or clinically manifest dementia (DSCID) is extremely challenging. As a direct consequence of these diagnostic difficulties patients tend to be misdiagnosed and thus mistreated.…