177 results
Primary Objective: Investigate whether EMDR Flash Forward is an effective intervention to process the mental images of worst case scenarios that occur in paranoid delusions, in order to decreases the preoccupation with the delusion.Secondary…
This study will rely on a well-replicated auditory-motor task combined with EEG in two separate experiments (Experiment. 1: speech manipulation and Experiment. 2: emotion and uncertainty manipulations) to elucidate how misattribution of simple (…
- Identifying phenomena and relationships/patterns through in-depth study of a limited number of cases and get insight in the impact of CCP for TRS on functioning, psychotic symptoms, quality of life, recovery, self-management, shared decision-…
The objective of this study is to examine the effect of riluzole on the glutamate/GABA balance in the brain in patients with 22q11.2DS. The secondary objective is to examine the effects of riluzole on psychotic symptoms and cognitive functioning. In…
The primary objective is to investigate the potential effect of the AIDP on global functioning in patients with SSD, BD, AD, and PD. Secondary objectives are to investigate whether the AIDP has a beneficial effect on cognitive functioning, well-…
This research aims to generate knowledge about the sexual experience of clients with an SMI. Possibly the acquired knowledge can be used to create awareness among care providers. The ultimate wish is to adapt the treatment to the sexual experience…
The objective of this study is to assess the added value of polygenic risk scoring in psychiatric genetic counseling for patients with serious mental illness (SMI) and their family members. The secondary objective of this study is to explore…
Primary objectives:Is IBA an effective treatment for patients with paranoia, that is, does IBA result in reduction of paranoia symptoms?Secondary objectives:Does insight improve after IBA treatment (i.e. insight in psychosis)?
To examine the PVS domain, and in particular reward circuits and behaviour, in large genetically informative cohorts comprising 500 individuals (including 125 SCZ patients, 125 BP patients, 125 relatives and 125 controls) already ascertained in the…
1. Distinguish and characterise linguistic voice-types2. Examine differential working mechanisms of voice-types3. Exploratively evaluate the role of voice-type in treatment effectiveness4. Disseminate the results to clinicians and voice-hearers
Our main aim is to test the effectiveness of a personalized sport intervention, which aims to promote social integration through sport activities in the community.
- To assess platelet (dys)function in adults with 22q11.2DS and its association with bleeding history.- To identify alterations in metabolic pathways in 22q11.2DS that may be of relevance to mechanisms underlying neurodevelopmental and…
The objective of the study is to identify the phenomenological differences and similarities in characteristics of voices between patients with a dissociative identity disorder and patients with a schizophrenia spectrum disorder with and without a…
The aim of the proposed study is to investigate the presence of dopaminergic abnormalities, as measured with [11C]raclopride, in relation to antipsychotic medication discontinuation in patients remitted after a first-episode psychosis (FEP).…
Primary objective:The primary objective is to answer the following research question:1. How do people who transitioned to psychosis describe alterations in their experiences of self and reality prior to the first psychotic episode? 2. Are these…
1. To examine whether there is an increase in (nigro)striatal dopaminergic functioning in individuals of West-African descent relative to those of Dutch descent (assessed in older participants with DAT SPECT and with NM-MRI in the entire sample). (…
In preparation of a larger intervention study, the aim of the current feasibility study is to test and improve a personalized sport (psychomotor therapeutic) intervention for young people in the first episode of psychosis.
The aim of this study is to combine acoustic characteristics from spontaneous speech and results from tests at different linguistic levels e.g. the Diagnostic Instrument for Mild Aphasia (DIMA), to determine which aspects in speech are most…
Primary: - Examine longitudinal developmental trajectories of structural and functional brain metrics in relation to genetic, clinical, psychological, environmental, and cognitive information in familial high-risk offspring and control children (…
objective is to assess feasibility, tolerability and efficacy of aiTBS in patients with bipolar depression (BPD) and negative symptoms of schizophrenia (NSS).