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Grumpy or depressed? Disentangling normative irritability from early signs of depression among adolescents with cell-phone micro-measures of daily mood swings.

Objective: We would like to differentiate *normative mood swings*. in adolescence from early signs of depression. A comparison between low-risk adolescents and an at risk and a clinically referred sample is needed to detect an unrecognized subsample…

Disrupting the rythm of depression: effectiveness and cost-effectiveness and mediating factors of preventive cognitive therapy, with or without antidepressants and compared to antidepressants alone, in the prevention of recurrent major depressive disorder.

The objective of this study is threefold:1) compare the effectiveness and cost-effectiveness of brief CT added to maintenance AD versus maintenance AD alone versus guided tapering or discontinuation of AD with brief CT.2) examine whether the…

Long-Term, Open-Label, Safety Study of LY2216684 12 to 18 mg Once Daily as Adjunctive Treatment for Patients with Major Depressive Disorder Who are Partial Responders to Selective Serotonin Reuptake Inhibitor Treatment

The primary objective of this study is to evaluate the long-term safety and tolerability of LY2216684 administered once daily (QD) in the adjunctive treatment with a selective serotonin reuptake inhibitor (SSRI) for up to approximately 1 year in…

Diagnostic Imaging of Affective Disorders using Emotion-processing in non-depressed patients
(DIADE-II).
A neuroimaging study to determine biomarkers to discriminate unipolar and bipolar depression

We aim to (1) improve differential diagnosis of recurrent MDD and BD by investigating biomarkers at a neuropsychological and neurobiological level ; (2) investigate whether affective neuropsychological testing can be used as a diagnosios tool for…

The relation between free serotonin in plasma, serotonin in trombocytes and the genotype of the serotonin transporter in carcinoid patients, patients on selective serotonin reuptake inhibitors and healthy controls.

To determine the influence of the serotonin transporter activity on the plasma free serotonin and dopamine amount and the stored amount (in trombocytes) in three different populations (healthy controls, carcinoid patients and patients on medication…

Attentional processes in depressed and non-depressed adolescents

1) To examine whether adolescents with depression, show abnormalities during specific attentional processes, compared to normal controls, 2) To determine whether abnormalities in attentional processes can be considered as prognostic markers of a…

Development and effectiveness of a webbased psycho-educational self-management intervention for breast cancer patients.

The purpose of this study is to develop a webbased intervention for breast cancer patients to reduce the impact of psychological problems that arise after the completion of medical treatment at an early stage. The question is whether this…

A randomized, parallel, double-blind, placebo controlled trial to investigate HPA-axis activation before and after electro-convulsive therapy in patients with a major depressive episode using an orally administered 5-HTP challenge test

Primary:1. to investigate the serotonergic HPA-axis activation (cortisol, ACTH, prolactin) in patients with a major depressive episode, using a newly developed oral 5-HTP-challenge administered before the first ECT treatment.2. to investigate the…

Effects and costs of a combined screening and treatment program
for elderly (aged 75 years and over) with depressive symptoms
in general practice

To study the effects and costs of a screening and treatment program for elderly with depressive symptoms in general practice.

A double blind, randomized, placebo controlled four way cross-over trial to investigate the effects of metoclopramide on central vasopressin release and HPA-axis activation

Primary:1. To establish the effect of MCP on the release of plasma AVP and subsequent ACTH and cortisol secretion in the absence of a 5HTP-challenge.2. To establish the effect of MCP on the release of plasma AVP and subsequent ACTH and cortisol…

Screening for depression in palliative care patients in general practice and hospital

The main objective of this study is to determine the validity and feasibility of the Beck Depression Inventory (BDI-II), the Hospital Anxiety and Depression Scale (HADS) and a short screening (3 questions), as a screening instrument for the…

Detection and treatment of major depression in patients with somatic illnesses admitted to the general hospital

The aim of the study is to:1. assess the prevalence of depression in patients with somatic illnesses admitted to the general hospital and to examine which self-report questionnaire is most suitable to screen for depression in this setting;2. to…

International Study for the Prediction of Optimized Treatment - in Depression

The overall objectives of the iSPOT-D trial are to use standardised genetic-brain-cognitionprotocols to:1. Identify markers of MDD as a diagnostic group and its subtypes2. Identify markers which change with acute (8 weeks) drug treatment in MDD3.…

A double-blind, randomized, placebo controlled, single oral dose, two way cross-over trial to investigate the effects of an orally administered 5-HTP challenge test on hypothalamic fMRS activation in healthy male volunteers.

Primary Objectives:- To investigate the effects of a single dose (plasma concentration) 5-HTP challenge test (5-HTP200mg/CBD100+50mg/granisetron2mg) on hypothalamic fMRS activation patterns in healthy male volunteers.Secondary Objectives:- To assess…

Attachment relationships and (introjective and anaclitical) vulnerability factors to depression: Idiographic assessment with the Self-Confrontation Method

The objective is this study is fourfold: (1) The primary objective is the (construct-) validation of the SCM-typology. (2) A second objective is to explore the idiographic narrative assessment of depression.(3) A third objective is to explore the…

A double-blind, randomized, placebo-controlled, cross-over, single center, pharmacodynamic trial to collect data for quantitative modeling of HPA axis modulation with desmopressin and CRH in healthy volunteers

Primary objectives:1) Describe the PD effects on plasma ACTH and serum cortisol upon 100 µg hCRH injection with or without a preceding injection of 10 µg dDAVP 2 hours earlier and study the PK-PD relationship (*Block B*). In particular, the outcome…

Serotonin-transporter polymorphism, early life events and emotional information processing

The aim of this study is to further investigate the relationship between 5-HTTLPR genotype and emotional processing. Recent literature suggests that s allele carriers of the 5HTT have a greater risk of developing depression in response to stressful…

PCI vs thrombolysis in acute myocardial infarction: a prospective study on the effects of cardiac and psychological risk factors on prognosis and quality of life SUBSTUDY: Endothelial dysfunction in ACS patients with and without depression

the proposed study will examine the differences in flow-mediated vasodilatation of the brachial artery in depressed and non-depressed post-MI patients.

Translation, cross-cultural adaptation and validation of questionnaires for Turkish and Moroccan Dutch patients with mood, anxiety and/or somatoform disorders and a comparison between native Dutch and Turkish and Moroccan immigrant patients

Our aim is to make ROM suitable for patients of Moroccan or Turkish origin. In order to achieve this, necessary steps need to be taken: (1) translate and cross cultural adapt ROM questionnaires; (2) validate the translated questionnaires; and (3)…

Systemic damage and quality of life in patients with ANCA-associated vasculitis

Primary Objectives: 1. To assess the prevalence of AAV related damage in AAV, i.e. cardiovascular damage and impaired QOL.Secondary objectives2. To assess whether there exists an association between cardiovascular disease, QOL and disease activity…