457 results
To determine the effects of hypercaloric HFHS snacking in the morning or evening on insulin sensitivity and serotonin function in the diencephalon.
To determine the direct effects of morning light intensity on postprandial glucose and lipid metabolism and metabolic gene expression in adipose tissue in obese subjects with and without type 2 diabetes.
The primary objective of this study is to assess if cannabinoids modulate sweet taste intensity and liking.
The aim for this study is to investigate feces composition and postprandial effect, as done with oral fat loading test (OFLT), on endotoxemia (e.g. LPS and Ralstonia levels) in plasma as assessed with qPCR.
To investigate whether ingestion of 4 grams of butyrate daily during 4 weeks can positively affect the immune system function, residual betacell function and low grade inflammation in patients with type 1 diabetes mellitus.
1. To assess whether acute TRPV1 activation by capsaicin or ENaC down regulation by flavonoids modulate osmoregulation in healthy subjects2. To assess whether capsaicin and flavonoids affect blood pressure
Based on our hypothesis that orally administered GOS will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we aim to address the following primary objective: To…
To determine the direct effects of morning light intensity on postprandial glucose and lipid metabolism and metabolic gene expression in adipose tissue.
The results of this research will elucidate the differences in oxygen tension and further effects for both adipose tissue depots in obese, insulin resistant woman. A recent study showed an increased oxygen tension in obese insulin resistant subjects…
To determine whether pulmonary rehabilitation prior to bariatric surgery leads to improved and sustained asthma control (ACQ) as compared to bariatric surgery alone in patients with morbid obesity and not optimally controlled asthma.Secondary aims…
Hypertension is characterized by vascular remodelling and endothelial dysfunction. Sphingolipids such as ceramide and sphingosine-1-phosphate may play an important role in regulation of vascular contractility and tonus. In this study the altered…
Main objectiveTo investigate whether the sympathetic stimulation of BAT, as assessed with a MIBG SPECT-CT scan, differs between lean and obese individuals.Secondary Objectives: To investigate whether the slope of the correlation between sympathetic…
Primairy objective: To investigate whether the sympathetic stimulation of BAT, as assessed with a MIBG SPECT-CT scan, differs between young and elderly subjects.Secondary Objectives: 1) To investigate whether the slope of the correlation between…
To determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, to assess the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and…
To investigate whether increased aldosterone levels in obese individuals lead to impairment of microvascular function through reduction of NO-availability, and to establish the role of microvasculaire dysfunction in the pathogenesis of salt-…
To investigate the feasibility and safety of a diet containing 30% caloric and 70% protein restriction given during five days in healthy kidney donors planned to undergo a live kidney donation as well as persons awaiting bariatric surgery.…
To investigate whether in obese subjects meal timing during a hypocaloric diet is related to the brain serotonergic system and insulin sensitivity as well as to food-motivated behavior.
To investigate the effect of elevated levels of endogenous lactate on brain lactate accumulation and on counterregulatory responses to, symptomatic awareness of and cognitive function during hypoglycemia in patients with T1DM with and without…
The aim of this study is to investigate the effect of a single bout of NMES on post-prandial muscle protein accretion during the day and prior to sleep in healthy elderly males.
Studying the GLP-1 response to a 75 grams oraal glucose load in 10 ZA and 10 WE healthy lean males to see whether GLP-1 is involved in the pathogenesis of T2D in ZA. 1. To investigate whether young lean healthy SA males without a family history of…