22 results
To further characterize the transport of phenylalanine and other large neutral amino acids across the blood-brain barrier in PKU patients with high and low brain vulnerability to elevated blood phenylalanine concentrations, we will investigate…
1. to determine whether the oxidation of BCAA (leucine) is impaired in patients with T2DM and in humans at risk to develop T2DM (first degree relatives). 2. to investigate whether an altered leucine oxidation in muscle is associated with insulin…
To investigate whether twice daily local (calf muscle) NMES attenuates muscle loss during 2 weeks of unilateral ankle immobilization due to an ankle fracture.
The aim of this study is to investigate the effect of a single bout of NMES on post-prandial muscle protein accretion during the day and prior to sleep in healthy elderly males.
To investigate the effects of 5 days of one legged knee immobilization with or without daily NMES on quadriceps CSA, lean mass and muscle fiber characteristics.
The aim of this study is to investigate the effect of a single bout of NMES on muscle protein synthesis rates in healthy elderly males.
The aim of this study is to investigate the overnight effect of a single bout of NMES on muscle protein synthesis rates in healthy elderly males.
To investigate whether elderly individuals lose muscle mass at a greater rate than young individuals during 5 days of one legged knee immobilization, and whether dietary protein supplementation can alleviate such muscle loss in the elderly.
STUDY 1: To investigate the impact of prior ingestion of a single high protein meal on the normal obligatory increase of muscle protein synthesis rates after protein intake and physical activity in healthy young men. STUDY 2: To investigate the…
The main objective: to evaluate the prescribed intake of micronutrients and fatty acids from natural protein and amino acid mixtures, and to correlate it to blood levels of these micronutrients and fatty acids, in patients with PKU. Secondary…
Objective of the study:1) To assess insulin sensitivity and response in critically ill septic neonates and children.2) To determine protein balance in septic, critically ill children at baseline and during a HyperinsulinemicEuglycemic Clamp, while…
To determine whether the T1405N SNP in the CPS-1 gene is associated with lower plasma L-arginine concentrations in preterm infants and to determine whether the T1405N SNP in the CPS-1 gene is associated with a higher risk of NEC.
Based on this background information and our preliminary data in this project we aim to perform longitudinal study in cystinosis patients to correlate clinical course under cysteamine therapy and 1) Markers of macrophage activation in patients…
The influence of different levels of protein diet on protein oxidation measured by 13CO2 breath test
The aim of this study is to determine whether our 13CO2 breath test is discriminative for different protein diets in healthy young volunteers.
To investigate the effect of preoperative protein supplementation on Hoffa*s fat pad, synovium, tendon, bone, muscle, ligament, menisci, and cartilage protein synthesis of the OA knee.
The present study aims to assess the feasibility of deuterated water dosing in critically ill patients to assess long-term in vivo skeletal muscle protein synthesis rates.
To assess the impact of short-term forearm immobilization on forearm muscle glucose uptake and amino acid net balance and kinetics of individuals with T2D compared with a control group with normoglycaemia.
To study the metabolic fate of amino acids derived from muscle protein breakdown in septic patients.
To investigate the effect of multiple sessions of whole body NMES, with or without consecutive protein intake, on muscle protein synthesis.
To test whether our breath test differentiates between a baseline state and two different levels of exercise (15 minutes at 30% of VO2 max and 15 minutes at 60% of VO2 max) in 16 healthy volunteers, thereby confirming or denying that protein…