312 results
The primary objective is to assess neuropsychological function in X-ALD patients without active cerebral demyelinating disease. Data of minors will be compared to matched healthy controls. Data of adults will be compared to reference values. The…
Protocol page 17The Mapping for Transvenous Phrenic Nerve Stimulation Study (MAPS) is being conducted to evaluate the feasibility of transvascular stimulation of phrenic nerves via an EP catheter advanced into the great veins.
The aim of the proposed study is to obtain insight into the needs, functioning and quality of life and changes in these outcomes of people with severe MS who are treated in NU and to identify the experiences, facilitators and barriers using the…
The primary objective is to study if quantitative (3- and 7-Tesla) MRI protocols (MRI perfusion, diffusion tensor imaging (DTI), and chemical shift imaging (CSI)) are able to detect phenotype conversion earlier than conventional MRI. Results will be…
Various brain areas play a crucial role in both pain and cognition, supporting the existence of a close relationship between pain and cognition. Consequently, it is important to examine whether pain experience changes at the moment the patient shows…
Patients with chronic respiratory failure currently start their ventilatory support in hospital as stated in national guideline. However, as these patients are severely disabled, a stay at the hospital for several days is experienced by many as very…
We aim to conduct a five year follow-up amongst the X-ALD carriers and assess their current symptomatic and biochemical status. This data will provide new insights in the progression of the disease in carriers. Moreover we would like to validate a…
The current study is part of a larger project that aims at identifying genetic profiles that render subject vulnerable to pronounced memory decline at old age. This part of the project will assess cognitive functions in three different age cohorts…
Previous studies have suggested an association between FD and cognitive impairment but these were flawed either by lack of power, used variable assessment of cognitive functioning and/or merged results of different phenotypes and sexes. It is of…
Concordance between MET diagnosis with and without the use of ultrasound with the chart review definitive diagnosis will be studied. Also other secondary endpoints will be evaluated.
To evaluate measurement properties and feasibility of the self-report Northwestern Ego-Integrity Scale in patients with ALS (or its variants PMA and PLS)
The aim of this study is to investigate the effects of DMF (Tecfidera) on the association between fatigue and fatigability measures in pwRRMS starting with DMF medication.
Primary aim is to validate the SART as a screenings instrument for driver fitness in patients with narcolepsy and idiopathic hypersomnia.
The main objective of this study is to determine the language representation in the brain of children with SLI and 22q11DS.
We aim to extend our recent work on fundamental mechanisms that underlie automatic influences of reward on attention to clinical populations that suffer from reduced and excessive reward-driven behaviours. That is, we will investigate whether…
The aim of the current study is to identify couplings of muscle activation patterns (muscle synergies) in reaching movements in stroke patients. Insight in the motor control of stroke patients can contribute to improve the disabled arm functioning…
The primary objective of this study is to determine the prevalence of white matter lesions and subjective/objective neurocognitive functioning in women several years after pregnancy compared to nulliparous women The secondary objective is to…
How does motor fatigue influence the cognitive functioning of patients with MS and how does this interaction compare to that in healthy controls?
Primary ObjectiveTo investigate changes of CSF proteins over time using continuous CSF sampling for 36 hours, including but not limited to A*1/x-42, A* 1/x-40, A* 1/x-38 and A* 1/x-37 in subjects with MCI or AD. Secondary Objectives1. To investigate…
The current study will examine psychological predictors of fluctuations in mood in the daily life of patients with CM. First, we will examine the role of within-subjects factors (headache, goal disturbance, rumination) in explaining daily…