63 results
We aim to extend our recent work on fundamental mechanisms that underlie automatic influences of reward on attention to clinical populations that suffer from reduced and excessive reward-driven behaviours. That is, we will investigate whether…
The main objective of this study is to characterize the features and the extent of extracerebellar structural pathology in SCA3 and SCA6 patients. Secondary objectives are:- To explore the sensitivity of DWI and other imaging modalities in detecting…
1. We will recruit 6 probands who experience cerebellar movement disorders with spinocerebellar ataxia features such as uncoordinated movement (i.e. asthenia, asynergy, delayed reaction time and dyschronometria) in limbs and organs such as the eyes…
The main goal of this study is to investigate the side effects of deep brain stimulation in Parkinson's disease. An important aspect of these side effects is the reward-oriented behavior. For this reason, patients will be administered…
This study tests the ability of the Cue-shoe, a new cueing device, to provide patients with FoG with successful cueing.
Obtaining fundamental insight into sensorimotor integration in Parkinson's disease, targeted on (i) the relationship between cognitive deficits and prosodic anomalies, and (ii) the effect of music on the motor aspects of speech production.
Study cortical involvement in motor control using system identification techniques in the time and frequency domain.
We want to gain more fundament insight in disturbed sensorimotor integration in PD, particularly with regard to the impact of visual stimuli on the cerebral organization underlying gait control. Such knowledge provides arguments for targeted patient…
The primary objective of this study is to detect statistically significant differences between the most severely affected PD subtype and controls on 3T imaging parameters.
The aim of this study is to evaluate the influence of extreme fixed wrist flexion and ulnar deviation due to spasticity on bone shapes of the wrist bones. We want to compare CT scan-based three-dimensional reconstructions of the spastic wrist to the…
To investigate the opinion of physicians about euthanasia and/or pysician assisted suicide in HD patients, in The Netherlands and surrounding European countries.To investigate the opinion of patients about euthanasia and/or pysician assisted suicide…
The main objective of this study is to detect potential biomarkers for the differentiation of PD and DLB and the differentiation of PD subtypes by using neuroimaging.
To test the suitability of the PortaLite fNIRS device for measuring brain activity during dual tasking performed by elderly with Parkinson*s Disease (PD) and design a valid and feasible protocol for this measuring.
The aim is to further track the course of motor symptoms and functional status, and to establish conversion to Parkinson*s disease dementia (PDD).
The objective of this study is to provide a reliable overview of the oral health of Parkinson's disease patients in the Netherlands.
The main goal of this study is to investigate the influence of STN DBS on the cognitive processes of reward processing and selective visual attention.
To gain experience with a fine-wire intramuscular measurement technique for recording of short-latency muscle responses in neck muscles.
The primary objective of the proposed feasibility study is to determine the willingness of patients to be randomized to CLI or DBS. Furthermore it will serve as a pilot trial for a future larger randomized controlled trial. For this larger trial,…
In the present study, we investigate the role of the STN in different conditions.In earlier research, we found that the STN is involved in response selection and inhibition. This was investigated using behavioral measurements. Currently, we want to…
The aim of this pilot study is to evaluate whether precise HDsEMG-guidance improves the therapeutic effect of BTXA. Because of its minor functional importance and focused endplate distribution, the extensor digitorum brevis (EDB) muscle is selected…