71 results
This study tests the ability of the Cue-shoe, a new cueing device, to provide patients with FoG with successful cueing.
The main objective of this study is to characterize the features and the extent of extracerebellar structural pathology in SCA3 and SCA6 patients. Secondary objectives are:- To explore the sensitivity of DWI and other imaging modalities in detecting…
The main goal of this study is to investigate the side effects of deep brain stimulation in Parkinson's disease. An important aspect of these side effects is the reward-oriented behavior. For this reason, patients will be administered…
1. We will recruit 6 probands who experience cerebellar movement disorders with spinocerebellar ataxia features such as uncoordinated movement (i.e. asthenia, asynergy, delayed reaction time and dyschronometria) in limbs and organs such as the eyes…
We want to gain more fundament insight in disturbed sensorimotor integration in PD, particularly with regard to the impact of visual stimuli on the cerebral organization underlying gait control. Such knowledge provides arguments for targeted patient…
The primary objective of this study is to detect statistically significant differences between the most severely affected PD subtype and controls on 3T imaging parameters.
This project has three separate but complementary research objectives. First, to find out whether there is indeed evidence of subclinical cerebellar dysfunction in these subjects, by specifically focusing on cerebellar motor learning. Second, to…
The aim of this study is to evaluate the influence of extreme fixed wrist flexion and ulnar deviation due to spasticity on bone shapes of the wrist bones. We want to compare CT scan-based three-dimensional reconstructions of the spastic wrist to the…
To test the suitability of the PortaLite fNIRS device for measuring brain activity during dual tasking performed by elderly with Parkinson*s Disease (PD) and design a valid and feasible protocol for this measuring.
Obtaining fundamental insight into sensorimotor integration in Parkinson's disease, targeted on (i) the relationship between cognitive deficits and prosodic anomalies, and (ii) the effect of music on the motor aspects of speech production.
Study cortical involvement in motor control using system identification techniques in the time and frequency domain.
To investigate the opinion of physicians about euthanasia and/or pysician assisted suicide in HD patients, in The Netherlands and surrounding European countries.To investigate the opinion of patients about euthanasia and/or pysician assisted suicide…
To examine the effect of tizanidine on the system characteristics of the reflex in the upper extremity
To determine the feasibility and applicability of the intervention 'Traject' to improve the participation in work of young adults (16-25 years) with a chronic disorder.
The aim of this pilot study is to evaluate whether precise HDsEMG-guidance improves the therapeutic effect of BTXA. Because of its minor functional importance and focused endplate distribution, the extensor digitorum brevis (EDB) muscle is selected…
identification of the needs of families with juvenile Huntington's disease
The aim of this study is to gain understanding of the functioning of spinal reflexes in patients with MD, using a new method involving EMG, EEG and the wrist manipulator.
The primary objective of the proposed feasibility study is to determine the willingness of patients to be randomized to CLI or DBS. Furthermore it will serve as a pilot trial for a future larger randomized controlled trial. For this larger trial,…
The objective of this study is to provide a reliable overview of the oral health of Parkinson's disease patients in the Netherlands.
To gain experience with a fine-wire intramuscular measurement technique for recording of short-latency muscle responses in neck muscles.