136 results
To assess the association between baseline blood pressure and change in neurocognitive functioning after four years, and to assess whether baseline MRI phenotypes are predictive for changes in neurocognitive functioning after four years in the DANTE…
The primary objective of this study is to assess whether a liberal (6.5 mmol/l) transfusion strategy compared to a restrictive (6.0 mmol/l) transfusion strategy lowers the incidence of major adverse cardiac events (MACE). MACE is defined as a…
The main objective of this study is to assess the effect of an acute cardiovascular event on the local and the systemic inflammatory state in humans with AMI as well as the reversibility of these effects after 3 months.
Explore difference in perforating artery pulsatility index between two patients groups with small vessel disease (history of lacunar infarct and deeply located haemorrhage) and healthy controls.
The overall aims of the proposed project are 1) to establish biomarkers for identification of the underlying vascular disease in patients with ICH and 2) to characterize whether disruption of the blood-brain barrier, a key factor in secondary brain…
To detect ophthalmic differences between patients and controles. To detect (early) changes in the retina in (pre)symptomatic RVCL disease carriers, in order to find a *biomarker* for disease stage and progression.
Main study objective of this study is:To evaluate whether the 320-detector volumetric CT technology can replace carotid duplex scanning and TEE in the diagnostic workup in TIA/IS patients. Specific aims of this main study objective are:1. To assess…
Primary Objective: To assess which measures of microvascular function on 7T MRI are affected in patients with CADASIL, relative to controls.
To assess the efficacy of a TCC, a BTCC and a cast shoe with similar plantar soles on offloading the previous ulcer location in people with DM and peripheral neuropathy.
Area of interest (study setting): Specific aims:Transient triggers and chronic riskfactors (case-crossover and casecontrol)(1) To investigate frequency and strength of association between transient physical andpsychological triggers and early-onset…
To investigate whether an interactive internet-based intervention strategy targeting vascular and lifestyle-related risk factors can lead to improvement of cardiovascular risk profile and prevention of cardiovascular disease and whether this in turn…
The goal of the research is to apply balance perturbations during standing and walking, and capture the resulting stepping responses. These data will be used to develop and verify predictive models of foot placement. Such models might eventually be…
To assess whether temporary discontinuation of antihypertensive therapy in mildly cognitively impaired older patients on antihypertensive treatment improves cognitive and psychological functioning.
Primary: to study the frequency and characteristics of fatigue and cognitive disorders after minor stroke. Secondary: to gain more insight in the aetiology of post-stroke fatigue and evaluate the impact of post-stroke fatigue on personal and social…
The primary aim of the proposed study is to assess whether stenting for symptomatic vertebral artery stenosis >= 50% is feasible and safe. A secondary aim is to assess the rate of new vascular events in the territory of the vertebrobasilar…
The aim of this study is to compare the integrity of the corticospinal tract and cortical reorganization of shoulder girdle muscle representations in chronic stroke patients with and without GHS as well as healthy controls.
To further investigate the pathogenesis of DCI and its relation to gender, decreased fibrinolysis, increased coagulation, and hormonal factors in order to eventually pave the way for new treatment options.
To determine the incidence of hypopituitarism in patients after SAHTo identify neurological parameters that predict hypopituitarism after SAHTo determine the value of a Ghrelin test shortly after SAH, to identify subjects with GHD.To determine the…
1) to investigate cognitive functioning in lacunar infarct patients with and without periventricular white matter lesions; 2) to identify predictors for cognitive dysfunction in lacunar infarct patients.
Primary objective: to assess cortical activity post stroke in a repetitive way to determine cortical involvement in dedicated motor tasks and to relate cortical activity to clinical outcome prospectively after stroke. Secondary objective: to assess…