14 results
How does motor fatigue influence the cognitive functioning of patients with MS and how does this interaction compare to that in healthy controls?
Is subjective fatigue in patients with MS related to a combination of force reduction during a fatiguing task and depression score?
How large is the force decrease in patients with secondary progressive MS, what is causing this decrease. In addition, is the cognitive performance of secondary progressive MS patients influenced by a fatiguing motor task?
Primary Objective• To demonstrate feasibility of measuring deuterium incorporation into galactosylceramides within the quantitation limits of the assay, in human CSF after chronic dosing of D2O.• To develop a mathematical model to allow estimation…
To assess the usefulness (sensitivity) of magnetic resonance imaging (MRI) in detecting TCP-induced changes in neurobiological markers induced by engine oil fumes.
In the proposed experiments we intend to investigate both central and peripheral aspects of fatigue in MS patients using a combination of simultaneously applied techniques; twitch-superimposition, electromyographic (EMG) and force recordings and…
Aim: 1) To continue studying (the determinants of) the decline in functioning in the domains neurological deficits, physical functioning, mental health, social functioning and general health in the first 9 years after the diagnosis, and 2) to study…
To better understand the utilities of the new BETACONNECT device and characterize its contribution to adherence, we plan to prospectively follow-up MS patients using the device for 24 weeks.
We aim to determine the difference in uni- and bimanual coordination between young adults, older adults and MS patients. Additionally we want to determine the relation between the different measures of cortical inhibition and task performance.
The purpose of this study is to assess the feasibility of decoding multiple movements from sensorimotor cortex of people with late-stage ALS and healthy controls.
The main objective of this project is to validate a standardized volume measurement system (using eight in-house 3D printed phantoms) to allow for reliable atrophy measurements in MS, by quantifying between-scanner and within-scanner reproducibility…
synopsis:Primary:• To assess the health related quality of life (HRQoL) through the MSQoL-54 scale in highly-active relapsing multiple sclerosis (RMS) subjects treated with Mavenclad® for 2 years (24 months)Secondary:• To assess treatment…
• 1A: Does aging have additional effects on motor performance in persons with MS compared to age- and sex matched controls?• 1B: Does aging have additional effects on fatigue and fatigability in persons with MS compared to age- and sex matched…
Technological developments such as smartphones and consumer wearable devices (i.e. the Fitbit) provide novel opportunities for selfmonitoring of people with chronic diseases.Here, we aim to gain insight into the use of these technologies for studies…