268 results
The study will be performed in 2 parts, Part 1 and Part 2). The purpose of the study is to investigate how quickly and to what extent Olesoxime is absorbed and eliminated from the body. In addition, it will be investigated how safe Olesoxime is and…
To quantify the effects of several factors on muscle relaxation of the finger flexors measured with TMS. These factors are contraction strength (as a percentage of the maximum), stimulus intensity, muscle temperature, and position of stimulator coil…
This study aims to explore the effects on the achievement of goals and the ideal conditions of a ZORA robot-based play intervention within rehabilitation and special education for children with severe physical disabilities with a developmental age…
* Investigate the safety and tolerability of multiple ascending oral doses of DNL104 in healthy subjects* Characterize the pharmacokinetics (PK) of DNL104 in plasma and measure the trough concentrations of DNL104 in CSF* Explore the pharmacodynamics…
The primary objective of this study is to evaluate upper extremity and trunk function in persons with SMA in different stages of the disease using 3D movement analysis, muscle force measurements, surface electromyography and activity scales. The…
- To describe the variability in clinical characteristics and natural history of BMD.Secondary objective:- To assess the role of genetic, biochemical and radiographic markers on disease severity and variability of BMD.
The purpose of this study is to investigate how quickly and to what extent different doses of EUapproved Tysabri® are absorbed and eliminated from the body (this is called pharmacokinetics) and how the body responds to different doses of Tysabri (…
Primary objective: To longitudinally characterize alterations in electrophysiological biomarkers in ALS of peripheral excitability in relation to neurodegeneration. Secundary objectives:1. To determine the value of multi-muscle CMAP-scan outcomes as…