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Probing the role of sodium channels in painful neuropathies (PROPANE Study)

To investigate whether sodium and potassium mutations are found in a cohort of patients with small fiber neuropathy, painful diabetic neuropathy (versus diabetes patients with no or only minor symptoms) and in patients with breast, ovarium or…

Effect of infrapatellar nerve block on chronic anterior knee pain after tibial nailing.

To study the effect of a nerve block of the infrapatellar nerve with local infiltration with lidocaine or saline on chronic anterior knee pain after tibial nailing.Secondairy objectives:- to measure knee pain on a VAS for eight different activities…

A Randomized, Controlled, Long-term Safety Study Evaluating the Effect of Repeated Applications of QUTENZA plus Standard of Care versus Standard of Care alone in Subjects with Painful Diabetic Peripheral Neuropathy

Primary objective:To assess the safety of repeat applications of QUTENZA administered over a period of 12 months in subjects with PDPN.Secondary objectives:To assess the efficacy of repeat applications of QUTENZA administered over a period of 12…

Iontophoretic administration of S(+)-ketamine in patients with neuropathic pain

At this time, iontophoretic administration of S(+)-ketamine is a already in use as a treatment of peripheral neuropathic pain in several pain clinics In the Netherlands (including the pain clinic at the Medical Center in Alkmaar). Although this…

Study of the armfunction and follow-up of children from the region Groningen with conservative treated obstetric brachial plexus palsy.

The goal of this study is to describe the function of the arm of older children with an OBPP in terms of joint flexibility, muscle strength and active function. Also describe the participation level and the follow-up. This to look if the follow-up…

Development of a nociceptive test battery - inflammatory and neuropathic pain tests.

* Investigate the feasibility, applicability, safety, tolerability, and reproducibility of nociceptive tests in healthy volunteers.* Investigation of confounding factors including anxiety, personality, and subject sex.* Explore logistics,…

Development of Complex Regional Pain Syndrome (CRPS) Severity Score As A Clinical Tool To Monitor Disease Progression

The primary aim of the proposed multi-site study is to determine if the CRPS Severity Score can be used as a clinical bedside tool to monitor CRPS change in symptoms over time, specifically progression or regression. Various interventions will occur…

A randomized, four-way crossover, comparative bio-availability study of branded (Neurontin®) and three generic 800 mg gabapentin labels in healthy subjects under fasting conditions.

The aim of this study is to investigate the possible consequences of generic-generic substitution of gabapentin, a frequently used anti-epileptic drug.

Small fibre neuropathy in critical illness

to investigate if small nerve fibres are affected in patients with ICU-AW

International Second Immunoglobulin Dose in Guillain-Barre Syndrome patients with poor prognosis.

Primary objectiveTo determine whether a second IVIg dose in GBS patients with a poor prognosis improves functional outcome after 4 weeks.Secondary objectives To investigate whether: - a second IVIg dose in GBS patients with a poor prognosis improves…

The Trigger of the First Trial Effect: examing pure Sensory Polyneuropathy Patients

To determine the influence of a pure sensory polyneuropathy on balance correction in light of the first trial response and in light of multiple succesive identical perturbations, compared to healthy control subjects.

Problems of the Autonomic Nervous system in the Intensive Care

To investigate the relation between different autonomic function tests in critically ill patients.

Spinal cord stimulation for treating neuropathic pain after chemotherapy / radiotherapy; a pilot study

To demonstrate that SCS is capable of treating otherwise refractory neuropathic pain after chemotherapy / radiotherapy.