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Development of Complex Regional Pain Syndrome (CRPS) Severity Score As A Clinical Tool To Monitor Disease Progression

The primary aim of the proposed multi-site study is to determine if the CRPS Severity Score can be used as a clinical bedside tool to monitor CRPS change in symptoms over time, specifically progression or regression. Various interventions will occur…

A randomized, four-way crossover, comparative bio-availability study of branded (Neurontin®) and three generic 800 mg gabapentin labels in healthy subjects under fasting conditions.

The aim of this study is to investigate the possible consequences of generic-generic substitution of gabapentin, a frequently used anti-epileptic drug.

Small fibre neuropathy in critical illness

to investigate if small nerve fibres are affected in patients with ICU-AW

Ulnar neuropathy at the elbow: short-term follow-up using clinical, electrodiagnostic and sonographic data

Assess the natural course of UNE in patients with mild to moderate symptoms by using clinical, electrophysiological and ultrasonographic data

Phase 2a, Double-Blind, Placebo-Controlled, 2-Period, 2-Treatment, Crossover Study to Evaluate the Safety, Efficacy and Pharmacokinetics of Multiple Oral Doses of XPF-001 (400 mg bid) in Patients with Inherited Erythromelalgia

• To evaluate the safety and efficacy of multiple doses of XPF-001 (400 mg bid) for relief of pain in patients with IEM.• To evaluate the efficacy of multiple doses of XPF-001 (400 mg bid) for relief of vasomotor signs in patient with IEM.• To…

Correlation of joint stiffness and stiffness of the skin and the prevelation of carpal tunnel syndrome (CTS).

To clarify the aetiology of CTS and prognostic factors for the development of CTS.

International Second Immunoglobulin Dose in Guillain-Barre Syndrome patients with poor prognosis.

Primary objectiveTo determine whether a second IVIg dose in GBS patients with a poor prognosis improves functional outcome after 4 weeks.Secondary objectives To investigate whether: - a second IVIg dose in GBS patients with a poor prognosis improves…

The Trigger of the First Trial Effect: examing pure Sensory Polyneuropathy Patients

To determine the influence of a pure sensory polyneuropathy on balance correction in light of the first trial response and in light of multiple succesive identical perturbations, compared to healthy control subjects.

Neurogenic inflammation in diabetic polyneuropathy and Charcot neuro-osteoarthropathy: response to intracutaneous Candida albicans

To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…

Effects of ARA 290 on the regrowth of epidermal nerve fibers in normal volunteers and patients with sarcoidosis

In this study we will assess the effect of ARA290 on nerve damage by taking 4 skin bipsies during treatment.

Non-contact heat evoked vasomotor response in healthy subjects

To study the quantitative and qualitative relationship between a heat stimulus and the vasomotor response in healthy subjects and to determine the feasibility of this measurement setup for patients.

A study to investigate the pharmacodynamics, safety and tolerability of cutaneous capsaicin in healthy adult subjects.

-To investigate the feasibility, applicability, safety, tolerability, and reproducibility of addition of the capsaicin-heat model and the thermal grill to the existing nociceptive pain test battery in healthy subjects.-To investigate the feasibility…

Morphological and functional changes of the median nerve after neurolysis for carpal tunnel syndrome

The objectives of this study are twofold:1. To describe morphological and functional changes of the median nerve after neurolysis using US and NCS. 2. To correlate the morphological and functional changes to the clinical symptoms and signs

A randomized, single-center, double-blind, placebo-controlled, 2-way cross-over, single oral administration trial to evaluate blood-borne biomarker candidates to predict NOP receptor activation using GRT6010 as NOP receptor agonist in healthy human subjects.

Primair: To assess the change in the CD11b expression in leukocytes and in plasma concentrations of nociceptin after oral single dose administration of 12 mg GRT6010 compared to placeboSecundair:To assess the difference in area of the capsaicin-…

HIDES * (HIV Indicator Diseases across Europe Study)

Implement a survey initiative to assess HIV prevalence for one or more diseases and/or conditions within a specific segment of the population not yet diagnosed with HIV and that present for care with the specific disease/condition.

A cohort study evaluating upper extremity dysfunction after percutaneous coronary intervention using the radial artery as access route

The main objective of this study is to provide insight in the morbidity with regards to the upper extremity surrounding the radial access route in percutaneous coronary interventions.Secondary objectives are the following:• To provide insight at the…

Learning to attend to pain

By means of the administration of a visual search task, an associative learning task, and an antisaccade task, we aim to resolve the primary research question whether a painful hand (more than a non-painful hand) positioned nearby a visual stimulus…

A double blind, placebo controlled Phase 2 dose ranging study of the effects of ARA 290 on corneal nerve fiber density and neuropathic symptoms of subjects with sarcoidosis

ARA290 is a new drug against neuropathic pain and was succesfully tested in previous studies on patients with neuropathic pain due to diabetes and sarcoidosis. The current study involves sarcoidosis patients with pain due to neuropathy. The purpose…

The effect of spinal anesthesia on pain perception and
sedation in healthy volunteers

(1) To assess the effect of deafferentation on pain processing in the brain by task-fMRI(2) To assess the effect of deafferentation on reaction time (sedation) by task-fMRI(3) To assess the effect of deafferentation on endogenous pain modulation

Treatment of Complex Regional Pain Syndrome type 1: A randomized placebo controlled double-blind study with ARA 290, The CRPSARA Study

Study AimsPrimary Aim: This is a proof-of-concept study to evaluate the effect of ARA 290 in pain of patients with CRPS1 by means of once daily subcutaneous injection with ARA 290 for 4 weeks. Secondary Aims: * Assess the predictive effect of…