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A Randomized, Double-Blind, Placebo- and Active-Controlled Study of Carisbamate in the Treatment of Neuropathic Pain in Diabetic Peripheral Neuropathy Followed by a Blinded Extension Phase

OBJECTIVESPrimary ObjectiveThe primary objective is to evaluate the efficacy, safety, and tolerability of 800 and 1,200 mg/day of carisbamate compared with placebo in reducing the average daily pain in subjects with diabetic peripheral neuropathy (…

A SINGLE-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CROSSOVER PILOT STUDY WITH TRAMADOL TO VALIDATE TWO EXPERIMENTAL HUMAN PAIN MODELS AT THE KENDLE CLINICAL PHARMACOLOGY UNIT

To evaluate and implement the cutaneous electrical stimulation pain model at the Kendle Clinical Pharmacology Unit.To investigate whether these human experimental pain models can discriminate the analgesic effects of a single oral dose of Tramadol…

Randomized, double-blind, placebo-controlled study of the tolerability and pharmacokinetics of ascending single (TDU6964) and 14-day repeated (TDR6966) oral doses of SAR501788 and pilot food variability evaluation (FED6965) in healthy young male subjects - Tolerability and pharmacokinetics of 14-day repeated oral doses of SAR501788 in healthy elderly male and female subjects (TDR6967)

to assess the tolerability and safety after single oral ascending doses of SAR501788 in healthy young male subjects (Part 1)to assess the tolerability and safety after repeated oral ascending doses of SAR501788 in healthy young male subjects (Part 3…

Meralgia paresthetica
a study of diagnosis, prognosis and treatment

A. What are possible causes of MP and what patients variable are asssociated with MP. What is the natural course and prognosis of MP. What is the influence of MP on the quality of life.B. What is the diagnostic value of SSEP en nerve conduction…

Mechanisms of conduction block and axon loss in immune-mediated polyneuropathies

To obtain robust evidence for activity-dependent CB and depolarizing CB in CIDP or MMN. This may reveal specific mechanisms of axon loss and provide a rationale for additional treatment aimed at prevention of irreversible axon loss.

Peripheral Neuropathy Outcome Measures Standardisation Study

The ulitmate goal of the current study will be the presentation of a specific minimum core set of outcome measures to be used in future clinical and follow-up studies in patients with autoimmune mediated polyneuropathies.

A Phase I, Single-Centre, Randomized, Double-Blind, Placebo Controlled, Multiple Dose Study to Evaluate the Effect of tedalinab on ECG parameters, CNS Function and Pain Perception in Healthy Subjects.

Evaluate the effect of tedalinab on ECG parameters, CNS Function and Pain Perception in Healthy Subjects.

Development of a nociceptive test battery - acute pain tests

Primary Objective* Investigate the feasibility, applicability, safety, tolerability, and reproducibility of nociceptive tests in healthy volunteers.Secondary Objectives* Investigation of confounding factors including fear of pain, mood, age and…

Validation study: a newly developed neuropathic pain Heat-Capsaicin-Warmth (HCW) sensitization model.

Primary:Part I:- to determine the effects of gabapentin and remifentanil on the evoked area of hyperalgesia, area of allodynia, pinprick hyperalgesia and background pain using a newly developed HCW sensitization modelPart II: - to determine…

Measurement of joint impedance and estimation of reflex gains in shoulder and elbow muscles in patients with peripheral nerve lesions using a two degrees of freedom haptic planar device.

To investigate whether propriocepsis or reflexes are present after nerve reconstruction

Influence of S(+)-ketamine on Diffuse Noxious Inhibitory Control (DNIC) and offset analgesia (OA) in chronic pain patients (neuropathic pain, complex regional pain syndrome type 1, fibromyalgia) and healthy volunteers

1. Measure DNIC and offset analgesia in CRPS-1 patients, fibromyalgia patients and neuropathic pain patients;2. Compare DNIC and offset analgesia in chronic pain patients with DNIC and offset analgesia in healthy volunteers;3. Assess the effect of…

Injection with corticosteroids in the sulcus of the elbow (with ultrasound) in patients with an ulnar neuropathy and EMG abnormalities

Whether injection of corticosteroids with use of ultrasound in the cubital tunnel is effective in reducing the symptoms compared with patients with an ulnar neuropathy treated with an injection of NaCl 0.9 % (placebo). Both groups will get the usual…

Prognosis of Guillain-Barré Syndrome in Children.

The present study aims to assess the long-term outcome of patients who suffered from GBS during childhood. This outcome at least six months after diagnosis will be determined in patients previously seen at the department of Paediatric Neurology of…

Predicting corticosteroid response in inflammatory neuropathies

The objective of this study is to test the hypothesis that in patients with inflammatory neuropathies and conduction blocks, corticosteroid treatment leads to:1. Hyperpolarization and reduced excitability of motor axons. 2. An increase of the number…

Correlation of collagen compostion of the connective tissues and the prevalation of carpal tunnel syndrome (CTS).

To clearify the etiology of CTS and prognostic factors for the development of CTS.

Intravenous versus Subcutaneous Immunoglobuline therapy in Multifocal motor neuropathy

1. Primary objective:To evaluate whether subcutaneous immunoglobulin infusion is as effective as intravenous immunoglobulin in maintaining muscle strength in patients with multifocal motor neuropathy.2. Secondary objective:a) To evaluate whether…

Extensive neurophysiological investigation in Guillain-Barré patients, focussing on motor unit abnormalities and weakness

1)To determine the contribution of reversible dysfunction of nerve terminals to weakness 2) To identify electrophysiological patterns that improve classification of GBS patients, and that discriminate between patients with good and poor prognosis 3…

Effects of vibrating insoles on balance in diabetic neuropathy. Research into the optimal characteristics of the applied noise signal.

The objective of this study is to compare the effects of noise with different characteristics on balance in patients with diabetic neuropathy

Effect of Spinal Cord Stimulation in Painful Diabetic Polyneuropathy (PDP study) A pilot study

1) The objective of this study is to confirm the hypothesis that SCS leads to pain relief as indicated by the results of two former pilot studies (Tesfaye et al. 1996 and Vos et al. 2008). 2) The practical feasibility of the test procedures…

Decreasing acute peripheral neuropathy in patients treated with Oxaliplatin
(heated oxaliplatin versus oxaliplatin on room temperature)

Objective: Main object Does warming of oxaliplatin, during the two hours infusion period, reduces the acute peripheral neuropathy complaints of patients with a colo-rectal tumor more than 50% in comparison with the standard treatment?Secondary…