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**NeuroCue*, a randomized controlled study into the use of an electronic cognitive aid in patients with acquired brain injury*

1. Effectiveness: the study is aimed at increased independence of patients and thereby increasing quality of life and well-being of both patients and caregivers involved. 2. Usability: Use of PDA by patients; frequency and methods of use, prognostic…

recovery of visual field defects after stroke - a pilot implementation

The goal of the study is twofold: (1) to study whether the earlier observed positive *lab-results* (training effects) are also observed in a rehabilitation setting, using evaluation techniques that are common in such a setting. If we observe…

Visual Thinking Strategies, applied as treatment for people with chronic acquired brain injury.

Investigate whether critical thinking of people with executive function deficits as a result of brain damage can improve by VTS.

Evaluation of a standardized cognitive behavioural therapy programme of depression after traumatic brain inury or stroke.

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PITUITARY DAMAGE AFTER TRAUMATIC BRAIN INJURY;
Occurrence of growth hormone deficiency at long term follow-up and the beneficial effects of growth hormone substitution on cardiovascular performance, quality of life and functional abilities

To evaluate whether GH substitution in patients with an isolated GHD after TBI could reverse the severity of symptoms which characterize GHD.

The glutamate/GABA balance as novel therapeutic target for psychotic and cognitive symptoms in 22q11.2 deletion syndrome

The objective of this study is to examine the effect of riluzole on the glutamate/GABA balance in the brain in patients with 22q11.2DS. The secondary objective is to examine the effects of riluzole on psychotic symptoms and cognitive functioning. In…

A strategy game supporting goal management training intervention for the treatment of executive problems after acquired brain injury: A randomized controlled pilot study for usability and preliminary efficacy

The primary objective of this pilot study is to investigate the feasibility of GMT with a new game that incorporates strategy training inimproving executive functions in a pilot sample of brain-injured patients. This study investigates the usability…

REstoring CONsciousness with NEurostimulation of the Central Thalamus in patients with a persistent minimally conscious state (RECONNECT): a pilot study

To explore the efficacy of central thalamic DBS in restoring consciousness in MCS patients. Hypothesis: Central thalamic DBS improves the level of consciousness in MCS patients.

Home-based exergaming for enhancing resistance to falls after stroke (HEROES): Proof-of-principle evaluation.

This proof-of-principle evaluation aims to investigate whether a home-based balance training using an exergame (HEROES), following a single session of perturbation-based training improves reactive step quality in people with chronic stroke.

Evaluation of the Karman Line memory strategy training, a combined computerized and face-to-face compensatory treatment targeting memory complaints after acquired brain injury, using single-case experimental design methodology.

The primary objective is the evaluation of the potential positive effect of a compensatory memory strategy game on effective coping with memory problems and reducing subjective memory failures in ABI patients with memory deficits in the chronic…

Auricular vagal nerve stimulation combined with rehabilitation to enhance functional outcome in cerebral palsy patients with upper extremity deficits (AVANS study) Part1

The ultimate goal is to investigate whether aVNS can enhance cortical plasticity and improve functional outcomes during intensive rehabilitation programs in children with cerebral palsy. First, we aim to establish the extent of cortical plasticity…

A Randomized, Double-blind, Placebo-controlled Single Ascending Dose and Open-label Multi-dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intrathecally Administered ALN-APP in Adult Patients with Early-onset Alzheimer*s Disease (EOAD)

This study has been transitioned to CTIS with ID 2023-508363-79-00 check the CTIS register for the current data. Part AMain objectives: • To evaluate the safety and tolerability of single intrathecal (IT) doses of ALN-APP in adult patients with…

Evaluation of a Compensatory Brain Game supporting Goal Management Training intervention targeting executive function after Acquired Brain Injury using single-case experimental design methodology

The primary objective of this study is to assess whether the use of a compensatory brain game supported GMT treatment could be of interest in people with EF deficits after ABI, to improve goal achievement, their executive function performance during…

A Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ENX-102 at Plasma Steady State in Healthy Volunteers

To evaluate the safety and tolerability of ENX-102 following repeated doses in healthy volunteers

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel
Design, Prospective, 52-Week, Phase 2 Clinical Study to Evaluate the Safety and Efficacy of GV1001 Administered Subcutaneously for the Treatment of Mild to Moderate Alzheimer*s Disease

This study has been transitioned to CTIS with ID 2024-511610-20-00 check the CTIS register for the current data. Cognitive and functional abilities will be evaluated using psychometric scales (ie, cognitive subscale of the Alzheimer*s Disease…

A randomized, double-blind, placebo-controlled, parallel-group, phase 2 study to evaluate the safety and efficacy of CT1812 in subjects with mild to moderate Alzheimer's disease

The purpose of this study is to evaluate the safety and efficacy of two doses of the study drug CT1812 per day for six months in subjects with mild to moderate Alzheimer's disease. CT1812 will be compared with a placebo. A placebo is a product…

A Phase 1/2 Open-Label, Ascending Dose, Multicenter Study to
Evaluate the Safety and Preliminary Efficacy of AVB-101
Administered by Bilateral Intrathalamic Infusion in Subjects With
Frontotemporal Dementia With Progranulin Mutations (FTD-GRN)

Primary Objectiveo evaluate the safety and tolerability of a one-time, intrathalamic administration of AVB-101 in subjects with FTD-GRN.Secondary Objectiveo To evaluate the preliminary clinical and biomarker measures of efficacy of a one-time,…

A Phase 1, Randomized, Double-Blind, Placebo- and Positive-Controlled, Parallel-Group Study to Evaluate the Effect of LMTM on the Response to an Oral Tyramine Challenge and to Determine the Multiple-Dose Pharmacokinetics of LMTM.

Part 1:The purpose of this study is to determine whether LMTM inhibits monoamine oxidase (MAO). MAO is an enzyme (protein involved in reactions in the body) which breaks down tyramine. By giving participants tyramine which raises the blood pressure…

Touch; reducing pain in Parkinson patients study 1

To determine whether CT optimal touch reduces pain experience in PD patients.

A multicenter, randomized, double-blind, active-controlled study to evaluate the effects of LCZ696 compared to valsartan on cognitive function in patients with chronic heart failure and preserved ejection fraction

To evaluate the effects of LCZ696 compared to valsartan on cognitive function over 3 years in patients with HFpEF as assessed by the CogState cognitive assessment battery.