156 results
Protocol 1: To determine whether pituitary dysfunction is present at intermediate duration of follow-up after traumatic brain injuryProtocol 2: To determine whether injury to brain tissue that explains traumatic brain injury-induced pituitary…
High-field (7T) MRI and genetic biomarkers for neurocognitive impairment in type 2 diabetes melltius
The primary objectives: 1. To tailor and apply high-field multi-parametric and functional MRI techniques to identify cerebral biomarkers in DM2 and MetS patients compared to control subjects.2. To examine a specific set of genetic hypotheses in DM2…
To study the acute effect of HD on global and regional CBF.
Our objective is to obtain insight into whether and how the visual and auditory systems of hemispherectomized patients have adapted after brain damage and brain surgery in early life. For this purpose we will perform psychophysical tests and (…
Primary Objective: • To demonstrate that changes in blood pressure and cerebral perfusion (induced with paced breathing and the Cold-pressor test) can be assessed in the MRI using the combination of NIBP and rapid ASL measurements. Secondary…
To assess how measures of microvascular function on 7T MRI in individuals from the Rotterdam Study without a history of clinical stroke or dementia relate to:- Exposure to vascular risk factors - Severity of presymptomatic SVD lesions- Cognitive…
The general objective of this study is to gain more understanding of motor and cognitive impairment and the way these two are linked after stroke. There are two more specific objectives: exploring (1) the link between motor and cognitive impairment…
The main objectives are to understand how clinical markers and biomarkers previously identified in younger and older AD cohorts apply to the extreme elderly (90+ years old) and to identify novel biomarkers linked with resilience to developing…
Primary Objective: To test the feasibility of online neuropsychological assessments using the Amsterdam Cognition Scan (ACS) compared to classical neuropsychological assessments in patients with cancers with CNS involvement.
To investigate the effect of explantation of silicone breast implants on neuroimaging of the brain (fMRI) in ASIA syndrome patients to gain more insight in the neurophysiological basis and nociceptive system of ASIA syndrome due to SIIS and the…
Primary objective of this study: To establish glycocalyx properties of temporal lobe epilepsy (TLE) patients. Secondary objectives of this study:- To establish differences in glycocalyx properties of glycocalyx between TLE patients and controls.- To…
Primary ObjectiveOur primary objective is to investigate the effect of SVD-progression on the long-term clinical outcome. Secondary Objectives- To identify causes and risk factors related to an unfavourable clinical outcome over time- To identify…
This study has been transitioned to CTIS with ID 2024-517636-22-00 check the CTIS register for the current data. The main objective of the present study is to investigate the association between in vivo regional synaptic loss ([18F]SynVesT-1 PET),…
The objective of this study is to validate the VBMEG algorithm by comparing hd-EEG with fMRI activity. If validated, it will be validated that the accuracy of the VBMEG algorithm is improved when fMRI is incorporated to the source reconstruction,…
The objective of this study is to examine the effect of riluzole on the glutamate/GABA balance in the brain in patients with 22q11.2DS. The secondary objective is to examine the effects of riluzole on psychotic symptoms and cognitive functioning. In…
This study will investigate the potential value of CFX treatment, by prospective monitoring of functioning in patients that undergo this treatment. Likewise, aspects of the treatment that are important for patient experience will be systematically…
The primary objective of this pilot study is to investigate the feasibility of GMT with a new game that incorporates strategy training inimproving executive functions in a pilot sample of brain-injured patients. This study investigates the usability…
Primairy objective:Explore the prevalence of the ABI-effect, by mapping the participation level. Secundary objective:Substatiate the occurence of the ABI-effect, by mapping cognitive functions of patients and compare these to healthy controls.…
The primary objective is to evaluate longitudinal developmental changes in brain structure in patients aged 6-18 years with SCD. The secondary objective is to analyze the longitudinal relations between biomarkers, demographic characteristics, brain…
The objective is to identify which eye movement features are sensitive biomarkers for FTD. To answer this question, we will assess which eye movement features dissociate best between healthy controls, patients with FTD (familial and non-familial),…