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Value of NewTom 3G Cone Beam CT for the detection of periapical lesions

Primary objective: to assess the healing rate of apical periodontitis in cases that received a root canal (re)treatment, with the use of the cone beam computed tomography (NewTom3G) at the first or second year of recall.Secondary objective: to…

Direct Identification of Anastomotic leakage with Microdialysis in Abdominal surgery

Determinqtion of postoperative microdialysis values for pyruvate, lactate, glycerol and glucose after esophagectomy and gastric pull-upk, pancreaticoduodenectomy and sigmoid or rectum resection. Early detection of anastomotic laekage in patients…

Prognostic Factors for treatment and follow-up of patients after colorectal surgery

the investigation and evaluation of certain serummarkers for inflammation and tumoractivity during the followup of colorectal neoplasms, and the applicability of these markers during the followup of these patients or the evaluation of the effect of…

Validation of measurement instrument MATE to identify Axis I - psychiatric disorders (DSM IV) and Axis II - personality disorders (DSM IV) among patients seeking treatment at Tactus Verslavingszorg

Objective 1: Determine the diagnostic efficiency of the SAPAS.Objective 2: Determine to which extend MATE is capable of detecting personality disordersObjective 3: Determine to which extend MATE is capable of detecting psychiatric disorders.

PREdictive value of the Self-triagecard and Chlamydia trachomatis positivity rate in vocational School students (PRESS-study)

This study assesses the prevalence of CT and GC in vocational school students and assesses the validity and feasibility of the self-triagecard as a method to efficiently identify and treat CT positive youth and limit the spread of CT.

Analysis of vital skin wounds.

1) Immunohistochemical analysis of skin biopsies of wounds in clients of the GGD to pinpoint wounds in time2) Analyse new combinations / explore new markers using micro-array analysis of those wounds, to expand the method of analysis of skin wounds.

The effect of music therapy interventions on assessment and behavior changes in the number of coping skills and social adequacy on newly admitted forensic psychiatric patients (randomized prospective clinical evaluation research)

The proposed research has two main objectives. The first objective is to investigate behavioral change (on coping, social skills, and impulse regulation) of forensic psychiatric patients due to music therapy treatment. The second objective is to…

Mapping serotonergic function using pharmacologic Magnetic Resonance Imaging (phMRI) in healthy subjects and users of ecstasy

- To assess the usefulness of 5-HT phMRI (BOLD-, PWI and ASL based phMRI) in assessing cerebral 5-HT neurotoxicity when compared to SERT SPECT.- To assess which MRI technique (BOLD-, PWI or ASL) is best in assessing cerebral 5-HT neurotoxicity when…

Mapping dopaminergic function using pharmacologic Magnetic Resonance Imaging (phMRI) in healthy subjects and users of amphetamine

OBJECTIVES: -to assess the usefulness of DA-phMRI (task related fMRI, steady state fMRI and ASL based phMRI) in assessing amphetamine induced DA-neurotoxicity when compared to DAT SPECT.-to assess which MRI technique (task related fMRI, steady state…

Measurement of nociception and prediction of movement during combined general (sevoflurane/fentanyl)-epidural anesthesia in ASA I-III patients undergoing major abdominal surgery using bilateral frontal EEG measurements and hemodynamic parameters (pulse transit time, cardiac output, blood pressure and heart rate)

In the current study we will measure CVI in ASA 1-3 patients during elective abdominal surgery under fentanyl/sevoflurane/epidural anesthesia. We will monitor patient movement as primary correlate to CVA and cardiovascular parameters as secondary…

In vivo imaging of amyloid-beta deposition in Alzheimer's disease

1) to assess whether in-vivo abnormalities related to amyloid-β depositions can be detected in the cortical grey matter of AD patients using a 7T MRI system, and 2) to assess whether these abnormalities can be quantified. The future goal is to be…

Evaluation of pain management in Dutch burn centers

1) Documentation of patients' self-reports of background and procedural pain in Dutch burn centres.Research question 1: How many patients report procedural painscores on a Visual Analogue Thermometer (VAT) of 7 or more?Research question 2: How…

European ADHD in substance use disorders prevalence study.

- to document the presence of adult ADHD in different European populations of adult patients referred for addiction treatment- to obtain a reliable estimate of the prevalence of ADHD among adult patients with substance use disorders- to test an…

Heart rate variability as a measure of pain intensity in healthy volunteers

The objective of this study is to determine whether heart rate variability measures correlate with pain intensity measured by a visual analogue scale in healthy volunteers in whom pain is induced by local heat application.

Evaluation of cognitive function of patients treated with sunitinib or sorafenib (UMCONCO200904

Tot evaluate the cognitive function of patients treated with sunitinib or sorafenib for metastatic renal cell cancer or a GIST, in order to get more insight in the prevalence, typeand etiology of cognitive dysfunctioning during treatment with…

Changes in a composite variability index (CVI) and bispectral index (BIS) in response to standardized pain stimuli during propofol remifentanil infusion.

Main objective: to compare the accuracy of the changes in CVI in response to a standardized noxious stimulus during various targeted pseudo-steady-state concentrations of remifentanil and various steady state level of BIS as guided by propofol…

Coagulation disorders in trauma patients

Evaluation of the incidence proportion and severity of bleeding in trauma patients admitted to the shockroom of the VUmc.

Pilot study on the validation of fluorescence imaging of lymph nodes during colorectal lymphadenectomy, using indocyanine green.

Feasibility study: The potential use of intraoperative, ICG based, fluorescence imaging of LN*s during CRC lymphadenectomy.

Multi-unit microneurography and modeling of afferent responses of human muscle mechanorecpetors

The goal of this research is to determine whether multi-unit microneurography can be a practically useful technique for recording human muscle-afferent signals, and to determine which fiber types are present in the recorded signal to and from the…

Optimization of MRI protocols in patients.

The aim is the optimisation of MRI-sequences in patients for clinical and scientific purposes.