166 results
The objective of the current study is to investigate the individual sensitivity for the development of ILD after exposure to various triggers. Main focus will be the differences in the formation of and the protection against ROS as well as the…
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.
Primary objectives:1. To analyze the exact pathogenic mutations in the TCOF1 gene in TCS 2. To determine the severity, prevalence, natural course within the cohort TCS patients and potential metabolic and physical effects of OSAS in TCSSecondary…
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…
Primary Objective: 1) To investigate if the intestinal permeability acutely increases during physical activity (submaximal cycle ergometry or ADL test) in clinically stable patients with moderate to severe COPD; 2) To investigate if the intestinal…
To analyze the relation between reduction in BMI and reduction in the exercise induced fall of FEV1 after a diet-period of 6 weeks. Secondary we analyze the relation between reduction in BMI and the recovery of the lungfunction to baseline (measured…
To assess 1. the burden of allergic disease across Europe*s aging population2. the association of severe asthma with potential risk factors and their impact on lung function decline over time3. the association of asthma severity with sex hormone…
Primary objective is to show the presence of endogenous ligands of TLR4 in the lung of patients being mechanically ventilated in a standardised way with clinical parameters. Secondary objective is to investigate the amount of endogenous ligands of…
The objective of the study is to get more insight into the interpretation of multiplex PCR test (which are so sensitive, that falls positive samples due to colonisation, or interpretation problems due to mixed infection may occur) and to expand a…
Goal of this study is to obtain more insight into causative agents of respiratory tract infections in children using molecular techniques and how results of molecular test should be interpretated in relation to clinical symptoms. The optimal…
The aim of the project is to investigate the effects of five contrasting air pollution scenarios on respiratory and cardiovascular health of young healthy volunteers.
Phenotyping of patients who are in an early state of adult-onset asthma (< 1 year the physician diagnosis of asthma and > 18 year of age) by linking clinical, functional and non-invasive inflammatory markers will:*Reveal distinct risk…
The aim of this study is to investigate if there are genetic factors predisposing to Löfgren*s syndrome, and whether these factors have an influence on the clinical course.
To investigate the role of different ADAMs (e.g. ADAM10 and ADAM17) in cigarette smoke extract (CSE)-induced production of inflammatory parameters (TGF-* shedding, MUC5AC and IL-8) in primary epithelial cells and compare the effects in cells derived…
Study 1: The objective of this study is to thoroughly characterize a large group of patients with non-atopic asthma clinically, functionally and with respect to inflammatory parameters and define 3-4 major phenotypes of this disease using unbiased…
Primary aimTo apply the CGT (intravenously and arterial sampling) in patient with multiple organ failure for the assessment of enterocyte function as a measure for intestinal (small bowel) barrier function.Secondary aimsTo compare the CGT with other…
To compare the levels of vitamin D in subjects with non-atopic asthma to those in subjects with atopic asthma and those in healthy non-atopic subjects
Primary Objective: To investigate the effect of supplementation of a single high dose of vitamin D (400.000 IU) on 1. the percentage of neutrophils in induced sputum, in non-atopic asthmatic patients with neutrophilic airway inflammation (…
We hypothesize that local AMPs expression in the airways of patients with asthma is decreased as a result of allergic inflammation. Furthermore, we hypothesize that local AMP expression can partly be restored by vitamin D substitution therapy. We…