262 results
The primary objective of this study will be to evaluate the cardiac adaptation due to hemodynamic changes in monochorionic twin pregnancies complicated by TTTS and sIUGR, by evaluating the size and the growth pattern of the pulmonary artery and the…
With this study we aim to provide insight in the role of pulmonary RAS in the pathogenesis of ARDS in neonates and children. This study is performed in the context of a comparative study assessing the impact of age on the pulmonary RAS in ARDS. We…
Therefore, the aim of our study is to determine whether and when changes in sympathetic signalling in the RV of IPAH patients occur, using [11C]-HED and [11C]-CGP-12177 PET imaging.
The first objective of the study is to predict the prevalence of PH in sarcoidosis with pulmonary involvement, and to optimize the diagnostic approach in screening for PH associated sarcoidosis using the RHC as gold standard (Galie, 2009). The…
Objective: To compare platelet reactivity and formation of platelet-monocyte complexes between patients with COPD and age-matched controls and to relate this to systemic inflammation.
The Activation of Coagulation and Inflammation in Trauma (ACIT) study is designed to identify the clinically significant mechanisms and pathways by which inflammation and coagulation are activated immediately following major trauma, and how these…
With this research project, we will investigate the effects of smoking and oxidative stress on epithelial barrier function in patients with asthma and COPD.The most important research questions are:1) Does exposure of cultured human epithelial cells…
The study objectives are to measure the impact of swimming in chlorinated water on the upper and lower airways of children with and without *doctors diagnosed asthma* by means of the following methods: 1.Tympanometry after otoscopy 2.Airway…
This project is the cross-sectional part of a large-scale longitudinal follow-up survey in patients with adult-onset asthma. The objective of this part of the survey is to define different phenotypes of adult onset asthma and to detect risk factors…
The aim of this study is to identify direct markers of muscle and adipose tissue hypoxia in COPD and CHF patients in relation to the altered muscle oxidative phenotype and the putative mediators HIF-1α and PPARs/PGC-1. Insight in the underlying…
The objective of the current study is to investigate the individual sensitivity for the development of ILD after exposure to various triggers. Main focus will be the differences in the formation of and the protection against ROS as well as the…
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.
Primary objectives:1. To analyze the exact pathogenic mutations in the TCOF1 gene in TCS 2. To determine the severity, prevalence, natural course within the cohort TCS patients and potential metabolic and physical effects of OSAS in TCSSecondary…
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…
Primary Objective: 1) To investigate if the intestinal permeability acutely increases during physical activity (submaximal cycle ergometry or ADL test) in clinically stable patients with moderate to severe COPD; 2) To investigate if the intestinal…
To analyze the relation between reduction in BMI and reduction in the exercise induced fall of FEV1 after a diet-period of 6 weeks. Secondary we analyze the relation between reduction in BMI and the recovery of the lungfunction to baseline (measured…
To assess 1. the burden of allergic disease across Europe*s aging population2. the association of severe asthma with potential risk factors and their impact on lung function decline over time3. the association of asthma severity with sex hormone…
Primary objective is to show the presence of endogenous ligands of TLR4 in the lung of patients being mechanically ventilated in a standardised way with clinical parameters. Secondary objective is to investigate the amount of endogenous ligands of…
The objective of the study is to get more insight into the interpretation of multiplex PCR test (which are so sensitive, that falls positive samples due to colonisation, or interpretation problems due to mixed infection may occur) and to expand a…