81 results
We aim to assess gene expression patterns in cilia-producing cells from healthy controls to develop a candidate gene list for PCD.
To estimate the incidence of S. aureus and P. aeruginosa ICU pneumonia, especially VAP, and to assess its association with patient-related and contextual factors, e.g. colonization status, serum antibody levels against S. aureus alpha toxin [AT],…
This study is designed to test if consumption of a vegetable extract as a food ingredient improves resistance to an experimental respiratory tract infection with RV16 in healthy volunteers.Primary Objective: * To test and quantify the effect of the…
This research project aims to determine the feasibility of setting up a randomized controlled trial to study the effects of different fluid management protocols on the outcome of mechanically ventilated pediatric patients with acute infectious lung…
Objective of the study is to quantify the microbiological etiology in immunocompromised patients, at least 18 years of age, with CAP needing hospitalization. And to determine the severity, antibiotic use and outcome of CAP in immunocompromised…
Primary Objective: *To study differences in pulmonary function (i.e. increased airway resistance) one year after hospitalisation for RSV LRTD between mechanically ventilated and non-ventilated infantsSecondary Objectives: *To study…
The aim of this study is to compare the time course of cytokines (markers for inflammation) in the following 3 groups: RSV-positive, ventilated patients; RSV-positive, non-ventilated patients and RSV-negative, ventilated patients. The main…
1. To evaluate the burden of disease of CAP and other LRTI in elderly in primary care in terms of duration of symptoms, number of hospitalization and mortality, and number of complications.2. To evaluate the burden of disease of CAP and other LRTI…
The primary objective is a) to study the occurrence of recurrent wheezing following hospitalisation for severe RSV LRTD, and to study the differences in occurrence between ventilated and non-ventilated infants, and ) to study differences in lung…
To determine the genetic risk of susceptibility to, or severity of community-acquired pneumonia by comparing the interpersonal genetic variation of the host immune response of patients with community-acquired pneumonia to healthy controls and by…
To determine the effectiveness of sputum induction in retrieving good quality sputum, identifying bacterial and viral pathogens in lower respiratory tract infections and determine the practical applicability of sputum induction in general pediatric…
The primary objective is to study the level and time course of lung inflammation and lung injury of ventilated infants with RSV LRTD. Secondary objective include studying the correlation between the level and time course of lung inflammation and…
Validation of microbiological analyses of BAL (broncho alveolar lavage) fluid in patients suspected of nosocomial bacterial aspiration pneumonia.
The aim of the CO-PRINCE study is to establish the efficacy and safety of long-term antibiotic prophylaxis with co-trimoxazolein children with recurrent upper and/or lower respiratory tract infections (including ear-nose-throat (ENT)).
To obtain insight in the role of the innate immune response, especially Type 1 interferons, in the pathogenesis of RSV LRTI. New techniques are used to unravel the local (nasopharyngeal) immunological milieu during viral LRTI. The hypothesis is that…
The primary objective of the study is to compare the efficacy of intravenous immunoglobulin product with the efficacy of antibiotic treatment in patients with recurrent respiratory infections and IgG-subclass deficiency and/or selective anti-…
To determine if maintenance therapy with AZN will provide significant improvements in PCD lung disease, compared to placebo: reduction in respiratory system exacerbations and improvement in lung function, ventilation inhomogeneity, improvement in…
The overall aim of the proposed project is to identify mild PID in elderly patients that distinguish patients with RRTI from individuals with a healthy ageing innate and adaptive immune system. In innate immunity, normal immunosenescence is…
Investigate if preoperative IMT affects the incidence of postoperative pneumonia after esophageal resection.
Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.