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Lambert-Eaton myasthenic syndrome: Clinical characteristics, pathogenesis and tumour association

- To study the clinical characteristics and disease course of patients with LEMS with or without SCLC- To identify the characteristics of the humoral or cellular immune response that are associated with the prolonged survival of patients with SCLC…

Identifying protein profile differences between laryngeal cancer of young and elderly patients: a pilot study.

Identification of protein profile differences between laryngeal cancer of young and elderly patients. Secondary objective is to identify differences between protein interaction network in cancer and healthy tissue in young and elderly laryngeal…

Evaluation of radiation induced pulmonary hypertension using MRI in stage III NSCLC patients treated with chemoradiotherapy. A Pilot Study.

The objective is to test the hypothesis that radiotherapy for lung cancer induces an increase in pulmonary artery pressure.

Diagnostic Accuracy of an Electronic Nose as Compared to Combined Conventional CT-Scanning, Autofluorescense Scopy for the Detection of Early Endobronchial Squamous Cell Cancer after prior History of Head-and-neck Cancer or Lung Cancer

To evaluate the value of volatile organic compounds analysis by eNose in the early detection of second primaries or metastasis (and early lesions).

Brown adipose tissue activity in lung cancer

To study the effect of early tumour development on brown adipose tissue activity

Spectroscopy in lymph nodes during Endoscopisch Ultrasound-Fine Needle Aspiration (EUS-FNA) procedure in patients with lung cancer

Development of a new technics to improve the diagnostic value of an EUS procedure in combination with reducing the amount of biopsies.

A diagnostic Study of European and Japanese advanced NSCLC patients to evaluate suitable sample types for EGFR testing: The ASSESS Study

This study will investigate if it is possible to perform the EGFR mutation test using blood samples. If successful, this study may mean that in the future, the mutation test can be done using a blood sample, and that patients may not need to have…

Quality of life, cognitive function, and physical fitness of patients surviving more than 2 years after immune checkpoint inhibitor therapy

Primary Objective: - to investigate health-related quality of life (HRQoL) of patients surviving 2 years or more after the first cycle of an immune checkpoint inhibitor for melanoma or NSCLC.Secondary Objectives:- to assess neurocognitive function,…

Analysis of food reward system and taste perception in cachexia induced by acute or chronic disease

To study activity in the reward-circuitry of the brain in patients suffering from cachexia induced by cancer.

Proteogenomic approach to reveal age-specific molecular mechanisms of laryngeal squamous cell carcinomas

Identify molecular differences in carcinogenesis of LSCC between younger and elderly patients through an integrated proteogenomic analysis of laryngeal tissue biopsies that could optimize personalized treatment of elderly patients in particular.

Prediciting Radiation-Induced lung injury through patient-specific lung epithelial ORganoids

To demonstrate the validity of using patient-derived lung epithelial organoids, as a model of normal lung tissue, we aim to assess lung epithelial cell responses to ionizing radiation exposure and relate these to clinical outcome. In addition,…

Brown adipose tissue activity and energy metabolism in cachexia induced by cancer or chronic disease

To study BAT activity and energy metabolism in patients with cachexia induced by cancer or chronic disease.