572 results
Objectives: The following trial objectives for adult patients with plasma therapy-sensitive Atypical Hemolytic-Uremic Syndrome (aHUS) are to:Primary:* Assess the effect of eculizumab on TMA-Event Free status defined as the absence of [1] decrease in…
To demonstrate the accuracy of FLT-PET to be an early response parameter for haematological recovery.
Primary:Comparing EPO induced proliferation, G2/G0 ratio, and apoptosis of UT7-EPO cells between anemic and non-anemic CHF patients. Secondary:1. Comparing the levels of several circulating inhibitory factors (TNF-alpha, TGF-Beta, Ac-SDKP, INF-gamma…
Determine the ADAMTS-13 activity in patients with a history of TTP.
What is the effect of ex vivo incubation of plasma from patients with hemophilia A with or without inhibiting anti-factor VIII antibodies with recombinant human factor V mutants on activation of coagulation?
The objective of this study is to investigate if CEC are elevated in SCD (and if they could therefore serve as a potential tool for assessing SCD activity), and what the relation of CEC is to the patients medical history and to specific laboratory…
Primary objective:- To define the overall effect of oral Levothyroxine on coagulation parameters.Secondary objectives:- To define the specific effect of Levothyroxine on each tested coagulation parameters.- To define the specific effect of…
The determination of a panel of markers associated with endothelial cell activation and/or damage in patients with a hematologic malignancy, receiving intensive treatment, or sickle cell disease in relation to the effects of transfusion intervention…
To prospectively evaluate the safety and feasibility of a diagnostic strategy combining clinical probability, D-dimer testing, (serial) ultrasonography in patients with clinically suspected UEDVT.
1. To establish the prevalence of PH in our population of children with SCD by standardized echocardiography; 2. To investigate the predictive value of alveolar and bronchial FeNO for PH in SCD patients. 3. To establish (genetic) risk factors for PH…
The aim of this study is to evaluate the current practice of anti-infectious strategies in patients with an absent or dysfunctional spleen.
AimTo determine whether the prophylactic use of IVIg reduces the need for ET in neonates with Rh-D hemolytic disease.
Purpose: Determine the ADAMTS-13 activity in patients with a history of TTP.
The objective of the study is to gain new insights in the causes of a higher clopidogrel resistence in type II diabetes mellitus patients
The objectives are to:A. Identify subjects with VWD who may benefit from prophylaxis by determining patterns of bleeding prior to evaluation for enrollmentB. Study the effect of prophylaxis on bleeding frequencyC. Establish optimal treatment…
To reduce postoperative blood loss by improving platelet function in autologous blood donation
To assess whether increasing low hemoglobin levels to near normal accelerate functional recovery and shorten the revalidation period after hip fracture surgery in the elderly.
PrimaryTo assess the prevalence of anti-efalizumab positivity in two sub-populations of psoriatic subjects trated with Raptiva® in the framework of the CLEARESTTM study:- Subjects developing adverse events (AEs) corresponding to pre-specified newly…
our main objective is to determine whether additional folic acid to ferrous fumarate contributes to the increase of haemoglobin and the improvement of health status in post partum anaemia. Our second objective is to asses what the difference in…
To evaluate whether acute stress induced by a byngy jump alters the status of the innate immune system