128 results
To obtain an estimate of the prevalence of chlamydia and gonorrhoea among men and women aged 18 to 34 years.
Collection of blood and urine samples for estimation of the metabolomic and proteomic intra- and inter-subject variation for an extensive set of biomarkers in healthy male volunteers.
The primary objective is to assess neuropsychological function in X-ALD patients without active cerebral demyelinating disease. Data of minors will be compared to matched healthy controls. Data of adults will be compared to reference values. The…
The current study aims to develop a novel approach to assess VO2max without any breathing restriction at the mouth by measuring maximal oxygen uptake in a respiration chamber.
The proposed study will further examine the effects of pregnancy on the human brain, by investigating structural and functional connectivity, local metabolite concentrations and neural activity related to social cognitive and memory processes.…
Investigating and comparing two disorders (i.e., OCD and GD) with phenomenological different types of compulsive behaviors central to their pathology can elucidate common mechanisms of compulsivity in psychiatry - core features- as well as specific…
1. To validate accelerometer cut-points to asses physical activity and sedentary behavior of breast cancer survivors. 2. To investigate the validity of accelerometers, inclinometers, heart rate and oxygen consumption to assess time spent in…
Collection of skin tissue and blood samples from patients with mild to moderate psoriasis for efficacy testing of a reference compound, for subsequent testing of a new therapeutic in a humanized mouse model.
The aim of the project is to study the effect of "UCB1577571 en CA050_01953" on typical skin features of psoriasis. This information can establish the most effective compound, right formulation and dose for further clinical research.
Study i)Select the most valid and feasible accelerometer for measuring habitual physical activity in children with a mitochondrial disorderStudy ii)Measure the test-retest reliability of this instrument
1. To investigate short- as well as long-term outcomes in patients who underwent CAWR in the Academic Medical Center and St Marks Hospital London between 2004 and 2015 with hernia recurrence as primary outcome. Secondary outcomes involve morbidity,…
Original study:The goal of this study is to have a theoretically based understanding of how sub processes of self-concept development emerge in relation to each other. The primary objective is to test a neuroscientific model of self-concept…
The purpose of this study is to evaluate the effect of local ablative treatment or embolisation or SIRT on circulating NET transcripts (PCR score or NETtest). In particular, the variation of circulating NET transcripts will be correlated to NET…
The main objective of the current study is to identify task-general problem-solving processes in the brain, using model-guided and machine-learning-based analysis techniques applied to fMRI data. The secondary objectives are to identify the timing…
The aim of the project is to study the effect of GRTs on the synthesis and cytokine release in psoriasis lesions. Thisinformation can establish the right formulation and dose of GRTs for further research.
1. Determine whether different classes of epigenetic modifiers affect HIV-1-specific T cell immunity.a. Investigate whether HIV-specific T cell exhaustion can be reversed by inhibitors of different classes of epigenetic modifiers.b. Examine whether…
The aim of the basic research in the laboratory is to develop new treatments to repair large bone defects, repair cartilage defects or inhibit the progression of osteoarthritis (cartilage degeneration). We focus on the following questions:1.How can…
Primary objective- Short- and mid-term repeatability of mDLS and LSCI measures;- Comparison of blood flow obtained by LSCI and blood flow obtained by mDLS;- Comparison of coagulation status obtained by mDLS and coagulation status assessed by…
To assess the physiological effects of metformin and hypocaloric dieting on thyroid iodide uptake and thyroid function in healthy volunteers.
We aim to validate MRS with a cholinergic challenge as method to investigate muscarinic M1 receptor functioning. To investigate the relationship between the response to a muscarinic receptor antagonist with biperiden phMRI and [123I]IDEX SPECT…