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A prospective clinical study on the efficacy of collagenase clostridium histolyticum (CCH) injections in the thumb and first web space contractures in Dupuytren*s Disease

To evaluate the effectiveness of CCH as treatment for Dupuytren*s contracture in the thumb and first web space by assessing pre- and post treatment extension deficit and adduction contracture.

A Phase II, Open-label, Multicenter, Randomized Study to Assess the Efficacy and Safety of GSK1120212 Compared with Docetaxel in 2nd Line Subjects with Targeted Mutations (KRAS, NRAS, BRAF, MEK1) in Locally Advanced or Metastatic Nonsmall Cell Lung Cancer (MEK114653)

Primary: progression-free survival in the GSK1120212-group in comparison with the docetaxel group. Secondary: safety and tolerability, response rate, duration of response, overall survival, PK.

Training therapists to improve the therapeutic alliance: A randomized trial in a naturalistic setting

Our primary aim is to conduct a large-scale study that investigates the impact of a specialized alliance training and evaluates the effect of the alliance training on the treatment process and outcome. Our secondary aim is to learn more about the…

A randomized, double-blind, placebo-controlled, multi-center study of the safety and efficacy of Dexpramipexole in subjects with amyotrophic lateral sclerosis.

Primary:The primary objective of the study is to evaluate the efficacy of oral administration of dexpramipexole 150 mg twice daily compared to placebo for 12 months in subjects with ALS.Secondary:The secondary objectives of the study are to evaluate…

Randomised controlled study of dose reduction and withdrawal strategies of adalimumab and etanercept in rheumatoid arthritis: saving costs at what expense?

This study has 4 primary objectives:1: To compare the cumulative incidence of patients fulfilling prespecified loss of response/flare criteria in the intervention group with the usual care group after 9 months and after 18 months of follow up.2:To…

The effects of resveratrol on serum apolipoprotein A-I concentrations in men and women with low HDL-cholesterol concentrations.

The objective of this study is to evaluate the effects of resveratrol on apo A-I concentrations in subjects with low serum HDL-cholesterol (HDL-c) concentrations at baseline. Minor objectives are to study the effects of resveratrol in the same…

The hysteroscopic morcellator versus the bipolar resectoscope for removal of submucous myomas: a randomized controlled trial.

To compare the HM to bipolar resectoscopy for removal of smaller type 0 and 1 myomas in terms of efficiency and complications.

investigating the efficacy of cognitive behavioral therapy in patients with substance use disorder and comorbid ADHD. A randomized controlled trial with cognitive behavioral therapy.

The objective of this study is to investigate the acceptance, feasibility and efficacy of cognitive behavioral therapy in reducing ADHD symptoms for adult patients with ADHD and SUD. We will also investigate how substance use and craving are…

eMate - Intelligent online monitoring and support for chronic patients

Patients with chronic diseases require long-term adherence. Adherence can be improved by patient counseling as is common in disease management programs. However, personal counseling is expensive, especially given the fact that chronic patients will…

The effects of switching antidepressants on endoxifen exposure

Inhibition of CYP2D6 enzymes by SSRIs may lead to reduced endoxifen plasma concentrations and thereby possibly influence tamoxifen treatment outcome. Paroxetine is a potent CYP2D6 inhibitor and strongly reduces endoxifen plasma concentrations.…

Uremic Toxin Removal and Hemodynamics in Long-Hour Hemodialysis and Hemodiafiltration; A Randomized Cross-Over Study

The primary aim of this study is to compare the removal of (especially protein-bound) uremic toxins between 4-hour and 8-hour HD and HDF in order to evaluate the influence of dialysis duration and of convection on the removal of uremic toxins.A…

Randomized controlled trial of mindfulness training as complementary therapy in adults with structural heart disease

Objective of this study is to determine (1) whether mindfulness training has an additional clinical and psychological effect to standard care, and (2) whether offering mindfulness training is a cost-effective intervention, in adult patients with…

A randomized, double-blind, placebo-controlled, multicenter Phase II trial investigating two doses of EMD 525797 in subjects with asymptomatic or mildly symptomatic metastatic castrate-resistant prostate cancer (mCRPC).

The main objective of this study is to investigate of the drug EMD 525797 is better then no treatment with subjects with metastasized asymptomatic or mild symptomatic mCRPC. The efficacy and safety of the drug EMD 525797 is evaluated.Primary…

OMEGA: A Prospective, Multicenter Single-Arm Trial to Assess the OMEGA* Coronary Stent System for the Treatment of a Single De Novo Coronary Artery Lesion

To evaluate the safety and effectiveness of the OMGEA Coronary Stent System for the treatment of subjects with a de novo atherosclerotic coronary artery lesion * 28 mm in length (by visual estimate) in a native coronary artery *2.25 mm to *4.50 mm…

A Double-blind, Randomized, Placebo-controlled, Multicenter, Parallel-group Study with an Open-label Extension Phase to Evaluate the Efficacy and Safety of Adjunctive Perampanel in Primary Generalized Tonic-Clonic Seizures

Primary Objective* To demonstrate the efficacy of adjunctive perampanel therapy, compared to placebo on primary generalized tonic-clonic (PGTC)seizuresSecondary Objectives* To evaluate the safety and tolerability of perampanel in subjects with…

BeSt for kids: A randomized clinical trial to test the effectiveniss of different treatment strategies in patients with Juvenile Idiopathic Arthritis

The aim of this study is to investigate, by direct comparison, which of 3 treatment strategies is the most effective and safe. The treatment goal in all strategy arms will be inactive disease. When inactive disease is achieved according (to the…

An open label two-stage study of orally administered BKM120 in patients with metastatic non-small cell lung cancer with activated PI3K pathway.

The purpose of this prospective, multi-center, open-label, two-stage phase II study is to assessthe efficacy of BKM120, as measured by determining the PFS, in patients with pretreatedmetastatic NSCLC that exhibits PI3K pathway activation. BKM120…

The effect of non invasive brain stimulation on lower limb motor control

The primary objective is to assess the effect of tDCS using different electrode configurations on corticomotor excitability in the lower extremities of chronic stroke survivors and healthy subjects. Secondary objectives are (a) to assess the effect…

Multicenter randomized trial comparing short-term stenting versus balloon dilatation for dominant strictures in primary sclerosing cholangitis

The primary objective of the study is to compare the efficacy of single session balloon dilatation with short-term stent placement in PSC patients with a worsening of their cholestatic complaints.

A study to evaluate the response of whole blood stimulation with lipopolysaccharide or other inducers and its in vitro inhibition in healthy volunteers, and patients with a chronic inflammatory condition

At CHDR, experience has been gained with the assessment of the in vitro inhibition by MAP kinases of the LPS-induced TNFα release in healthy male volunteers. However, relatively little is known on the inhibition by MAP-kinases in other populations.…