572 results
The primary objective of the study is:- to establish the safety and feasibility of infusion of escalating doses of autologous ASC in end-stage renal disease patients. Secondary objectives are:- to determine the effect of ASC infusion on kidney…
The main objective of this study is to compare the incidence of KPTD in mildly renally impaired HBV-infected persons on TDF to the incidence in patients with normal renal function. Secondary goals are to relate tenofovir plasma, intracellular and…
- To evaluate the safety and tolerability of ascending single oral doses of ACT-462206 in healthy male subjects.- To investigate the single oral dose PK and PD of ACT-462206 in healthy male subjects.- To investigate dose proportionality across…
Measuerment of breathing frequency using the Respir8 facemask
Pertuzumab is an investigational agent being studied for the treatment of HER2-positive gastric cancer. This study intends to provide a dose of pertuzumab to find an acceptable minimum pertuzumabconcentratie pertuzumab effective when administered in…
- to assess the excretion balance of total radioactivity in urine and faeces after single oral dose of 20 mg 2.35 MBq (64 µCi) of [14C]-S 47445, - to determine the pharmacokinetics of the total radioactivity in whole blood, plasma and urine after…
Primary:To evaluate the feasibility of using unconjugated rotigotine saliva concentrations as a surrogate for unconjugated rotigotine plasma concentrations.Secondary :To evaluate the effect of time of food intake on rotigotine concentrations in…
To compare Clinical Target Volumes after RFIB (CTV-RFIB) and after BCS (CTV-POC).
Primary: Does immunomodulation brought about by interferon beta-1a (Rebif) enhance or prolong functional reorganization in subjects with RRMS?Secondary: Does interferon beta-1a (Rebif) also affects functional connectivity as measured by resting-…
- To educate adolescents about clinical drug studies by involving them as project team members and participants in an experiment with negligible risk and minimal burden;- To investigate the effects of paracetamol on nociception in adolescents; - To…
Determine whether phenylephrine or norepinephrine has superior haemodynamical effects in ophtalmic surgery
The PAPPA-trial was the first prospective clinical study the feasibility and safety of a DEB only strategy in PPCI for STEMI. One-year angiographic follow-up is warranted to evaluate long-term patency of the target lesion. So far there has not been…
The aim of this study is to assess the number of supragastric belches and reflux episodes before and after speech therapy in GERD patients with troublesome belching symptoms due to an increased number of supragastric belches.
To evaluate the effectiveness of SSO and to examine determinants of treatment effects.
The study will be performed in 3 parts, Parts 1, 2 , 3. and 4 (DDI). The purpose of the study is to investigate how safe the compound is and how well the compound is tolerated; this will be investigated in all study parts. In Parts 1 and 2, it will…
The primary objective is to assess the clinical efficacy of siltuximab (a chimeric (murine-human) IgG1* mAb that specifically binds human IL-6 with high affinity and prevents its interaction with the IL-6 receptor, glycoprotein (GP) 80),…
PrimairTo determine the MTD and/or RP2D of oral twice daily (BID) BEZ235 in combination with trastuzumab in patients with HER2-positive breast cancerSecondairTo assess the preliminary activity of the combinationTo assess the safety and tolerability…
To investigate the therapeutic effect of a selected probiotic mixture on the severity of AD in infants aged 0-15 months. The probiotic mixture has been studied in vitro and has proven IL-10 stimulating effects. Therefore it is thought to decrease AD…
Primary objectives: 1) To identify determinants for short- (completion of CR) and long-term (1 year after the start of CR) outcomes of cardiac rehabilitation 2) To determine whether results achieved during rehabilitation are predictive for the long-…
The purpose of this study is to demonstrate the added value of usingLMA Supreme* in the ambulance care in the Netherlands with CPR indigent patients. The hypothesis is that the value of using theLMA Supreme* is to be found in the safety and speed of…