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Unmet LDL-C target in very high risk cardiovascular patients

To assess the prevalence of LDL-C >1.8 mMol/L in a subgroup of very high risk patients with ASCVD, who remain at a very high-residual risk for ACS, despite treatment with high-intensity statins in combination with ezetimibe. This subgroup of…

The development of a prediction model for acute pain transitioning into pain persisting for more than 3 months after a visit to the emergency department

We hypothesize (based on literature) that the incidence of chronic pain in The Netherlands is around 15-20% in patients presenting to the emergency department with (acute) pain related complaints. We have no further hypothesis, because of the…

Become Active in Beating osteoarthritiS (BABS): A randomized controlled trial on the effectiveness of a promotional campaign in improving the management of osteoarthritis and quality of care

An information campaign was developed targeting early-stage KHOA patients and healthcare professionals (HCPs) to optimise timing of referral to secondary care.

Patient Engagement Counter Cauti with an App

By providing patients reliable information and daily checklists via an app, we aim to give the patient a tool to be involved in the management of the catheter use. In this way, inappropriate use should be better signaled and discouraged, and the…

Coaching On Lifestyle

Hypotheses are that the long-term supervision of the CooL intervention will be related to beneficial changes in the participants¡¯ energy-balance related behaviours, body composition, and quality of life. Besides, the goal of the intervention is to…

Aspirin for the prevention of spontaneous preterm birth

The objective was to assess the effectiveness of low-dose aspirin in the prevention of recurrent preterm birth.

The effect of smoking status on the treatment of non-small cell lung cancer with immunotherapy

Mortality will be lower in patients who do not smoke during treatment of non-small cell lung carcinoma with PD-L1-inhibitors compared to patients who smoke during their treatment with PD-L1-inhibitors.

Randomised Evaluation of Secondary Prevention by Outpatient Nurse SpEcialists

To quantify the impact of outpatient nurse-led prevention clinics on the risk of future clinical events in patients with symptomatic coronary artery disease.

A twelve-month, multicenter, randomized, open-label study of safety, tolerability and efficacy of Certican-based regimen versus calcineurin inhibitor-based regimen in de novo liver transplant recipient

The study is designed to show that Certican® initiation together with reduction and thereafter discontinuation of calcineurin inhibitor (CNI) will improve significantly renal function in de novo liver transplant recipients as compared to…

Comparing the effects of a new method to prevent constipation according to the usual method to prevent and to treat constipation bij patients lying in the hospital with a neurological disease.

The effectivity of a standard preventing constipation and treatment list, designed by the hospital nutritionteam, will show that neurological patients during their stay in the hospital develop less constipation.

Sexuality and the self: studying gender-, social- and cultural differences in sexual self-concept as an explanation for unplanned pregnancies and abortion in teenagers

Aim of the research is the development and evaluation of an intervention to promote the sexual and reproductive health of adolescents who differ in cultural background. Fundamental idea is that sex education is more effective if the information is…

Does Misoprostol facilitate insertion of an Intra Uterine Device (IUD), both copper-containing as well as levonorgestrel-releasing, among nulli- and multipara?

To investigate whether Misoprostol (compared to placebo) will diminish the amount of insertion failures. To investigate whether Misoprostol (compared to placebo) will diminish the amount of insertion related complications (eg. syncope, perforation…

Blood glucose homeostasis in type 2 diabetes: the effects of sacharose

The aim of this study is to investigate the glycemic effects of the consumption of soft drinks, under fully standardized nutritional conditions, in obese type 2 diabetes patients and non-obese and obese normoglycemic control subjects.

Prospective cohort study on the effect of surgical treatment of obstructive sleep apnea syndrome on blood pressure (and other cardiovascular risk factors).

In The Netherlands 2% of women and 4% of men suffer from Obstructive Sleep Apnea Syndrome (OSAS). NCPAP, the gold standard therapy for moderate to severe OSAS has been shown to reduce blood pressure in OSAS. NCPAP therapy is however hampered by…

RANDOMIZED CONTROLLED TRIAL TO REDUCE FALLS AND FEAR OF FALLING IN FRAIL ELDERLY

-To test the efficacy and determine the costs of a multifaceted intervention program to reduce falls incidence rate and fear of falling, and thereby improve mental wellbeing in community dwelling frail elders, with high level of comorbidity and…

Participatory interventions for return-to-work for temporary agency workers and unemployed workers sicklisted due to musculoskeletal disorders.
A randomised controlled trial and cost-effectiveness evaluation.

For this study the aim was first to adjust the parcipatory return-to-work method for employees with nonspecific LBP to the working methods and procedures of the national organisation, responsible for counseling, disability management and activating…

Preoperative physical therapeutic intervention for high-risk patients who are scheduled for elective total hip arthroplasty

Primary Objective: The primary objective is to investigate the feasibility of a short-term preoperative physical therapeutic intervention for frail elderly patients, who have a higher risk on postoperative complications or a delayed recovery, after…

On-line: Web-based Cognitive Behavioural Therapy (CBT) for Diabetic Adults with Minor to Moderately Severe Depression. A Randomised Controlled Trial.

This study aims to test the effectiveness and appreciation of a web-based cognitive behavioural therapy (CBT) program for adult diabetic persons with minor to moderately severe depression in a randomized controlled trial.

Implementation of a concept for active primary prevention of type 2 diabetes in a primary care setting.

Objective is to study the implementation of a proven cocept for active primary prevention of type 2 diabetes in a Dutch primary care setting, in order to assess whether such a concept can be applied on a broader scale, and as such contribute to the…

The effect of two different heart-lung machines, Twin-Pulse Life Support and standard used heart-lung machine, on the systemic inflammation and pattern of microvascular blood flow. A prospective randomised clinical trial.

Analysis of the effects of the Twin-Pulse Life Support on on the systemic inflammatory response and the effect on microvascular blood flow in ocmparison to standard used Extracorporeal Circuit Device