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From expecting to experiencing: The role of parenting cognitions in the transition to parenthood

Study 1 is aimed to describe normative trajectories of parenting efficacy from pregnancy to early parenthood. Study 2 is focused on the question whether mental representations of attachment are protective in the context of parenting stress and its…

Immunogenetic and therapeutic aspects of Autoimmune Hepatitis

Primary Objective: To gain more insight in the genetic susceptibility for AIH. For this we will study the presence of candidate genes in AIH patients, study genetic similarities with other auto-immune diseases and perform a whole genome association…

GENETIC DETERMINANTS OF MONOAMINE METABOLITE LEVELS IN HUMAN CEREBROSPINAL FLUID

Identification of genetic variations that control monoamine and amino acid metabolism in humans, by translating recent genetic findings in non-human primates to a human cohort.

Stenting of symptomatic vertebral artery stenosis. A randomised safety and feasibility study

The primary aim of the proposed study is to assess whether stenting for symptomatic vertebral artery stenosis >= 50% is feasible and safe. A secondary aim is to assess the rate of new vascular events in the territory of the vertebrobasilar…

Development of chronic disease in newly diagnosed Idiopathic Thrombocytopenic Purpura of Childhood. A randomized controlled study on the influence of treatment with intravenous gammaglobulin on the course of the disease.

To test the hypothesis that IVIG treatment diminish the risk of development of chronic disease, we designed a prospective clinical intervention study in children with newly diagnosed ITP.

part a) Follow-up brain imaging study in obsessive-compulsive disorder;part b) Frontal-striatal and limbic circuits in Tourette and OCD, a brain imaging study

Aims:a) Understand persistence and/or plasticity of the brain correlatesb) Understand specificity of the brain correlatesQuestions:a) Which neural correlates of OCD are state dependent and thus normalized after successful treatment?b) Which neural…

Modification of risk with MSCT- coronary angiography in high-risk cardiac asymptomatic patients.

To demonstrate whether using MSCT to reclassify individuals who are at high-risk based on traditional risk factors.

Functional connectivity of cortico-cortical and subcortico-cortical brain networks in Parkinson*s disease

This project aims to understand the symptomatology PD in the light of functional brain interactions, in the hope of elucidating the role of the frontal striatal system to behaviour.

Prophylaxis of venous thromboembolism in patients with a fracture of the lower extremity being treated conservatively with a below-knee plaster cast.

The purpose of this study is to determine the need for thromboprofylaxis in patients being treated in a below-knee plaster cast after trauma of a lower extremity and if there is, to assess if both of the two tested prophylactic treatments are suited…

Complications of PCOS Pregnancy: Evaluating Risk

To design a multivariate prediction model of pregnancy outcome in women with PCOS with the intention to define intervention strategies for the future.

Contrast Induced Nephropathy Evaluation using Multiple immunoAssays

The aim of the current study is to:1. Determine the incidence of CIN after introduction of preventive measures.2. Describe changes in the course of biomarkers serum creatinine, microalbumin and microglobulin related to intravenous ICM administration…

Characterisation of regulatory T cells and cytokine production in children diagnosed with asthma

To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.

Maraviroc Immune Recovery Study (MIRS):
A multicentre, randomized, placebo-controlled, exploratory mechanistic study into the role of Maraviroc on immune recovery

The primary objective is to confirm the hypothesis that Maraviroc stimulates immune recovery; the ssecondary objective is to explore, by virologic and immunologic investigations, the underlying mechanisms of this hypothesis.

An Open-Label, Randomized, Phase 3 Trial to Evaluate the Efficacy and Safety of Aztreonam 75 mg Powder and Diluent for Nebuliser Solution (AZLI) versus Tobramycin Nebuliser Solution (TNS) in an Intermittent Aerosolized Antibiotic Regimen, in subjects with Cystic Fibrosis followed by an Open Label, Single Arm Extension

The primary objective of this study is to assess the comparative safety and efficacy ofAztreonam Lysine for Inhalation (AZLI) and Tobramycin Nebuliser Solution (TNS) in adultand pediatric cystic fibrosis (CF) patients aged 6 years or older with…

An Open-Label Phase III Study to Assess the Safety and Immunogenicity of a Vero Cell-Derived Whole Virus H5N1 Influenza Vaccine in an Adult and Elderly Population as well as in Specified Risk Groups

- To assess the safety and tolerability of a nonadjuvanted H5N1 influenza vaccine in an adult and elderly population and in specified risk groups;- To assess the immune response to a non-adjuvanted H5N1 influenza vaccine in an adult and…

Pathogenesis of community-acquired pneumonia, chronic obstructive pulmonary disease and cystic fibrosis: mechanism of inflammatory response and the role of Th17 differentiation

To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis

The effects of prenatal exposure to nicotine and cannabis on brain
development at school age

What are the long-term consequences of prenatal exposure to cannabis and nicotine on the brain development of 6-year old children?

Double-blind, randomized, placebo-controlled, parallel group, multi-centre phase III clinical study on the efficacy and tolerability of mesalazine granules vs. placebo for the prevention of recurrence of diverticulitis

The objective of the study is to compare the efficacy and tolerability of mesalazine granules (3 g 5*ASA/d) vs. placebo for the prevention of recurrence of diverticulitis. Additionally, the safety and tolerability in the form of adverse events and…

Imaging genetics in Autism Spectrum Disorders

The objective of this study is to investigate the effects of replicated and theoretically interesting autism risk genes on brain anatomy in ASD. We will use psychiatric genetics and gene expression patterns to predict neuroimaging findings in ASD.

Pancreatitis, verY earlY compared wiTH delayed start Of eNteral feeding (PYTHON) trial: a randomised controlled multicenter trial.

To investigate whether a very early start of EN (< 24 hrs after admission), as compared to selective delayed EN (> 72 hrs), will lead to a lower rate of infectious complications and mortality in patients with predicted severe AP.