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SEP-study: The assessment of normal values in Stress Echocardiographic Parameters in
patients after successful mitral valve repair for organic mitral valve regurgitation

To determine normal values in stress echocardiographic parameters in asymptomatic patients at least 6 months after successful MV repair for organic MV regurgitation. These normal values for non-invasive 2D stress echo testing are of utmost…

Optical techniques in diagnosis and management of premalignant and malignant laryngeal and pharyngeal lesions.

Primary objective is to analyse whether transnasal videolaryngoscopy in outpatient practice is more accurate in determination of the extend of the affected mucosa of laryngopharyngeal tumours compared to direct laryngoscopy under general anaesthesia…

Renal cystic disease in lithium treated patients
assessment by MRI and renal ultrasound.

Primary Objective: The main objective of this study is to determine whether MRI and ultrasound are capable to distinguish the existence and extent of microcysts in a Dutch population of lithium treated patients.Secondary Objective(s): to determine…

Prospective evaluation of allergen-component resolved diagnostic allergy testing and its relation to clinical features of allergic disease in children

by improving the understanding of the relationship of CRD to clinical expressions of allergic disease in children, this study aims at generating data that can improve the development of tools that will help the primary or secondary care practitioner…

The Allergy Alert Test, a proof of concept study

The study will be designed as a multicenter study to evaluate the impact of several parameters influencing the sensitivity and specificity of skin self tests.The parameters are:- Product applied: hair colouring formula mixed with developer (in use…

Optical spectroscopy as a novel tool in the diagnostics of skin neoplasms.

Primary Objective: To quantify the tissue light scattering, absorbing and fluorescence properties of different stages of skin (pre)cancer using multi-diameter single fiber reflectance (MDSFR) spectroscopy. Secondary Objective(s): To correlate the…

Calibration of extracellulair fluid volume measurement by 125I-iothalamate in subjects with a low GFR using Bromide distribution volume.

Primary Objective: To calibrate the measurement of ECFV by 125I-iothalamate in subjects with a GFR <60 ml/min and GFR <30 ml/min, using an accepted measurement of ECFV: distribution volume of Bromide.Secondary Objective(s): To…

ClarityIQ Cardiac Image Processing for Cardiac Angiography for minimizing radiation and optimizing image quality

The objective of the study is to assess image quality and diagnostic information of images during coronairy angiography with lower X-ray dose compared to standard dose.

Affect dysregulation and Dissociation in Substance Use Disorder patients with comorbid Borderline Personality Disorder or Post Traumatic Stress Disorder.

To examine whether BPD SUD patients have more overregulation of emotionsthan BPD or SUD patients only and to examine whether overregulation In BPD SUD patientsIs moderated by dissociation. And to examine whether PTSD patients with SUD have…

Food allergy to soy:
"Characteristics of soy allergy profiles in relation to the severity of the symptoms after ingestion."

To investigate causes and predictors for primary or secondary allergy profiles for soymilk

Comparison of ABVS and HHUS
for detection and characterization of breast lesions

1. To evaluate wether ABVS could replace HHUS in women <30 year with focal breast signs2. To evaluate the performance of ABVS in comparison to HHUS in patients with high suspicion of breast cancer3. To start a pilot study to compare ABVS with…

Arthroscopic Optical Coherence Tomography in imaging of Trapeziometacarpal joint articular cartilage

In-vivo visualization of TMC articular cartilage using intra-articular fiber-optic OCT during TMC arthroscopy.

Functional Lesion Assessment of Intermediate stenosis to guide Revascularisation

To assess whether the iFR is non-inferior to FFR when used to guide treamtent of coronary stenoses with PCI

Validation of the Dutch version of the International Index of Erectile Function (IIEF) in patients with erectile dysfunction and controls

The present study is designed to validate the Dutch IIEF. The psychometric properties of the Dutch version of the IIEF will be investigated.

: Long-term follow up of growth and bone mineralization of former preterm infants

To determine whether increased calcium and phosphate intake (2005 group) resulted in improved Bone Mineral Content (BMC) and Bone Mineral Density (BMD) compared to the group with less calcium and phosphate intake (2004 group) at the age of 8-10…

Urinary Bladder Mapping

To monitor the electric activity of the urinary bladder, and to localize the pacemaker, and the path of electric signal propagation of the detrusor muscle contractions.

Vitamin C status in patients with chronic kidney failure

Vitamin C deficiency may play a role in the symptoms of patients with chronic kidney failure and eventually renal replacement therapy

Metformin vs Control to prevent gestational diabetes mellitus (GDM) in women with a high risk for GDM, an open label randomized controlled trial. The Medico-GDM trial.

The primary objective is to compare metformin versus no intervention for incidence of GDM in women with a high risk for GDM. The main secondary objective is pregnancy outcome with Metformin, neonatal outcomes and neonatal complications.

MRI of regional lymph nodes in cT1-3N0 breast-cancer patients and DCIS (cTisN0) patients

To assess the influence of sentinel-node biopsy (SNB) on visualization of regional LNs using newly developed MRI techniques.

Randomized, double blind, placebo-controlled trial of ubiquinol in a statin-induced mitochondrial dysfunction model in healthy volunteers.

Primary Objectives-To evaluate if mitochondrial dysfunction can be induced in healthy, middle aged subjects, through the use of simvastatin, and whether it can be reversed by oral ubiquinol supplementation. -To validate the techniques NIRS, PpIX-…