293 results
The primary objective of the study is to determine whether exercise training exerts a long term effect on maximal exercise capacity, clinical events, sports participation, serum NT-proBNP and quality of life in adults with a systemic right ventricle…
The study aims to answer the following questions: 1) What is the effect of Retigabine on cortical excitability measured by TMS ? (primary). 2) To what extent are changes in excitabilty meausred with TMS related to seizure control ? (secondary).
Our research goals are as follows: 1) identification of sleep and/or memory problems among 100 recently diagnosed TIA or small stroke patient,2) testing the relation between memory complaints and long term memory consolidation3) assessing the…
The overall aim of this study is to find objective and sensitive markers to predict short term and long term food challenge outcome. Primary Objectives: - Can we predict (severity of) short- and long-term food challenge outcome with clinical and…
Primary Objective: To investigate the role of testosterone, cortisol and serotonin in aggression (experimentally induced aggression and self-reported aggression over the last six month).Secondary Objective(s): the role of approach and avoidance…
to combine and validate diagnostic tests for the identification of preclinical very early RA (VERA) patients and prognostic tests for the prediction of progression
The primary aim of this observational study is to determine the occurrence of (exercise-induced) pulmonary hypertension (sPAP > 40 mmHg) in IIP patients with an elevated V*E/V*CO2 at AT (> 34) assessed during CPET. And, secondly to…
Therefore, the aim of this study is to determine normal-values for esophageal pressure characteristics using a water-perfused high-resolution manometry catheter. Furthermore, we aim to compare pres
The most important objective of this study is the validation of various examination procedure to assess fitness to drive in older persons with cognitive impairments. The assessment procedure comprises nosological dementia diagnoses (e.g. AD, FTD) ,…
To investigate the additional value of MRI and MRI-guided biopsy in men with an elevated PSA in the general practitioners* (GP) practice regarding the detection of both insignificant and significant cancer, and reduced biopsies.
The objectives of this research study are to perform a biomarker development study for salivary pSS biomarker confirmation and panel building. The findings will be analyzed against SS diagnosis based on ACR criteria: Aim 1To test individual…
To establish the safety and preliminary efficacy of Check-Cap*s P1 Capsule System in patients eligible for CRC screening
The objective of this cross-sectional study is to assess the relation between plaque characteristics, detected by Coronary Computed Tomography Angiography (CCTA) and Intravascular Optical Coherence Tomography (IVOCT), and the hemodynamic…
The main objective is to determine the effect of different anticoagulant and procoagulant agents on thrombin generation in whole blood and compare it to the effect on thrombin generation in PPP and PRP at different tissue factor concentrations. In…
The purpose of this investigation is to determine the prevalence of device-recorded ST segment changes occurring before appropriate ICD therapies (ATP or Shock) and to define their temporal relationship to ventricular arrhythmias.
Primary objective:Pharmacokinetics/-dynamics of 124I-F8IL10 Secondary objective:Dosimetric parameters of arthritic joints and internal organs.
Determine wether or not a strategy based on molecular analysis is effective in improving the PFS
The purpose of this study is to determine the thermal parameters by MRI scans at different time points during head-neck radiotherapy combined with hyperthermia treatment series.
To determine the incidence of posttraumatic osteoarthritis following distal radius fractures in a cohort of young non-osteoporotic patients and correlation with objective and subjective outcome measures.