273 results
To further optimize 7.0 Tesla MRI techniques and to develop new MRI techniques that will enable state-of-the-art clinical and cognitive research leading to improved patient care. Whereas some applications of 7.0 Tesla MRI already show improvements…
the objective of the current study is to evaluate the safety and efficacy of enzyme therapy in the Dutch population of patients with MPS I, II and VI; to compare this to the natural course of these diseases; to make an inventory of the direct and…
The main objective is to study pregnancy rates after using metabolomic profiling added to the selection of viable embryos by morphology, compared to using only morphology.
Primary aim: To investigate whether PET-CT (using [18F]FDG, [18F]Fluoride and [11C]PK11195 as tracers) visualizes inflamed tissues of AS patients, with clinical scores as reference Secondary aim: To investigate whether reduction of inflammation by…
To compare accuracy, patient experience and costs of lower gastrointestinal endoscopy (sigmoidoscopy and colonoscopy) between nurse and physician endoscopists.
The development of a valid and reliable test intended to measure functional motor activities in daily life of children with DCD.
The aim of this study is assessment of right ventricular function: a comparison between MRI and real-time 3-D echocardiography (RT 3-D echo). We have the following research questions: 1) Is assessment of right ventricular (RV) function with RT 3-D…
This study wants to evaluate on intraoperative MRI whether contrast enhancement at the borders of the resection cavity correlates with tumor tissue, and whether no contrast enhancement correlates with the absence of tumor tissue. To differentiate…
Primary: To investigate whether high-resolution MRI, 18F-FDG PET, and microemboli detection, or a combination of these techniques, enable to identify patients in the 30-69% stenosis group with an increased stroke risk. Secondary: To compare the…
Evaluation and comparison of sentinel node biopsy (SNB) and ultrasound guided fine needle aspiration cytology (USgFNAC) in the management of the clinically negative neck in patients planned for transoral excision of oral and oropharyngeal squamous…
1. To study the rate of change of diastolic and systolic LV function and LV structure, and the incidence of heart failure over a 7-year period in subjects with and without DM2 2. To study the potential determinants of accelerated deterioration of LV…
We need objective and validated tests for the assessment of the severity of impairment in CFS/ME patients. In 2 areas these tests will be essential: for studies of the effect of interventions and for the assessment of disability.Hardly any research…
Relation between mixed venous and central venous saturation in sepsis: influence of source of sepsis
Measurement in an observational setting of mixed en central venous oxygen saturations during the first 24 hours will provide interesting data. Not only can the influence of the sourse of sepsis on these data be described, but also the effect of…
Evaluation of the diagnostic value of stomach and small bowel mucosal oxygen saturation measurements in patients suspected for chronic gastrointestinal ischemia.Determination of normal mucosal oxygen saturation values in patients without chronic…
The project has the following objectives:1. To investigate the diagnostic value of beta amyloid oligomers in CSF and plasma for AD in subjects with mild dementia. 2. To investigate whether beta amyloid oligomers in CSF and plasma can predict AD in…
The objective of the standardized protocol is optimalizing the accuracy of the diagnosis (all-cause pneumonia, or serotype-specific pneumonia) during the 13-valent pneumococcal vaccin (13vPnC) study which will be performed in 2008. Additionaly, the…
The aim is to study if Neurofeedback can be an applicable intervention.for survivors of childhood brain tumours. The QEEG wil be investigated whether under or overactive brainareas exist which can be trained. This study will also investigate whether…
The aim of the present study is to evaluate whether there is an association between biomarkers (hs-CRP and BNP)
The goal of this research is to determine whether multi-unit microneurography can be a practically useful technique for recording human muscle-afferent signals, and to determine which fiber types are present in the recorded signal to and from the…
To investigate the clinical value of OptiVol (TM) impedance measurement by Medtronic(R) InSync Sentry(TM) ICD's. We aim to determine specificity and sensitivity for detecting heart failure. With collected data we want to design a protocol for…