86 results
The objective of this study is to demonstrate the clinical performance of VENTANA PD-L1 (SP263) CDx Assay in terms of its ability to identify patients with metastatic NSCLC who may benefit from treatment with acasunlimab (GEN1046) in combination…
The study will help us to determine 1. the necessary type of (combined) examinations and 2. the sample size that is essential to evaluate (future) genetic therapy in Usher syndrome type 2 and USH2A associated nsRP.
The objective of this study is to characterise and validate multidimensional latent risk and resilience mental health trajectories in a trans-syndromal sample of help-seeking young people, including identifying genetic, environmental, biological,…
The aim of this clinical study-part in the Netherlands is to identify demographic and clinical predictors of risk, diagnosis, and progression of heart failure. In the European study component, the objective is to eventually compute with this…
To investigate the influence of body posture on the measurement cervical sagittal balance parameters.
We aim to reduce total scan time and accelerate the conventional acquisitions in patients presenting with cardiovascular disease by evaluating the novel developed non BH 3D cardiovascular scan technique and the use of the adaptive-CS-network for CMR…
The primary objectives are to describe NDTs from double pulse IES stimuli before and 20 minutes after HFS induced secondary hyperalgesia, as verified by responses to mechanical pinprick stimuli, and describe EPs of detected double pulse IES stimuli…
To establish whether the decrease in pulmonary function as a result of wearing a neoprene suit is caused by restriction or obstruction, and which effect is has on pulmonary volumes.
The primary purpose of this study is to enhance the understanding of the disease progression in sepsis, particularly from ICU admission to the development of DIC. This will be achieved by investigating the association between various biomarkers with…
This study aims to determine feasibility of providing and following ICU discharged patient with smart technology for 3 months after hospital discharge from a general ward of the Leiden UniversityMedical Centre. If proven successful, home monitoring…
Primary objectives:• To characterize the central inflammatory response to IV LPS by measuring biomarkers in CSF• To characterize the systemic inflammatory response to IV LPS by measuring biomarkers in blood • Characterize CSF/Blood ratios for each…
Primary objective: 1. To validate the data quality and diagnostic accuracy of StrokePointer to detect LVO stroke among patients with a suspected stroke in the pre-hospital setting. Secondary objectives:1. To determine the user-friendliness of…
The primary objective is to investigate the concordance between the Endosign test and EGD by an expert endoscopist for detecting dysplasia and/or EAC in a high-risk category of ULSBE patients. Secondary objectives are to determine the acceptability…
Current laboratory tests for hypersensitivity are not sensitive of do not exist for certain allergens omong which medical drugs. To objective is therefore to optimize existing in vitro tests (lymphocyte activation and proliferation test, cytokine…
The primary objective of this study is to evaluate the clinical performance of the [REDACTED] PD-L1 [REDACTED] CDx Assay in terms of its ability to identify patients with squamous metastatic NSCLC (mNSCLC) who may benefit from treatment with […
The primary objective of this feasibility study is to provide an initial assessment of OA/US imaging to distinguish between benign and malignant thyroid nodules using HbO2 and HbR as the primary biomarkers.The secondary objectives are:- To…
To assess the post-operative quality of recovery after robot-assisted as compared to open extended lateral pancreaticojejunostomy.
The objective of this pilot study is to assess whether transportation of the sample via a pneumatic tube system (PTS) has any detrimental effects on the recovery of presepsin levels, when compared to traditional hand-delivery. This research will be…
The primary objective is to perform a clinical validation of the analytical method for dried blood spot microsampling of cabozantinib, pazopanib, sunitinib, Lenvatinib, nivolumab, ipilimumab, pembrolizumab, atezolizumab or bevacizumab. The secondary…
The primary objective is to examine the effect of twelve weeks supplementing daily one AstaPure® Oleoresin capsule on trans epidermal water loss (TEWL) in postmenopausal women. The secondary objectives are to investigate the effects on other skin,…