135 results
The primary objective is acquiring insights in the development of BOS in patients after human lung transplantation in an early phase of the disease which can be used to improve immunotherapeutic handling in order to prevent or delay the onset of BOS…
To obtain insight in the role of the innate immune response, especially Type 1 interferons, in the pathogenesis of RSV LRTI. New techniques are used to unravel the local (nasopharyngeal) immunological milieu during viral LRTI. The hypothesis is that…
The main aim of this study is to assess the prevalence of allergic and non-allergic health problems in veterinary students in different phases of the veterinary education. On later stage, genetic predisposition for allergies will be studied. In the…
The study objectives are:1. Getting insight into the biological origin of the typical serum protein profile in breast cancer by comparing the protein profiles in breast tissue of benign breast disease patients and primary breast cancer patients with…
The general objective of this study is to elucidate the cellular components for HIV-1 infection in children.
The goal of this study is examining the acute effects of insulin on microcirculation in hypertensive insulinresistant subjects and investigate if angiotensine II influences these effects. Amendement: The goal of the amendement is to exame the…
To examine the effect of surgical trauma on mucosal perfusion, intestinal epithelial damage, the inflammatory response and potentially sepsis, following surgery remote to the abdomen in adults, children and neonates,
Investigate effect of IF on insulin resistance and possible role acylcarinitin profiles and glycolipids
The main aim of this follow-up study is to assess the incidence of respiratory disorders, like allergy, asthma and asthma like-syndrome, in association with the interaction of environmental and genetic risk factors in veterinary students. In order…
The main objective of this research proposal is to 1). develop an on-line monitor for young athletes to prevent them from a systematic overload and to avoid overtraining 2) develop clinical tools to improve diagnostics of overtraining.
The Municipal Health Service The Hague and the LUMC are planning to conduct a study similar to the one in Pune in The Hague. In the start-up phase of this study we are preparing a pilot study in which we will study anthropometry and insulin…
To clearify the etiology of CTS and prognostic factors for the development of CTS.
1. to investigate whether the known chronic inflammatory and hyperoxidative state in patients with severely increased LDL is associated with dysfunctional HDL.2. to investigate whether CVD in FH is associated with dysfunctional HDL.
To determine, by measuring cIMT's, whether the abnormal lipid profile of GD I carriers and patients is associated with atherosclerosis and an increased risk of CAD.
The objective of the current study proposal is to gain insight in the effect of pulmonary vein isolation on the electrophysiological properties nearby the ablation lines on the posterior sight of the left atrium and further away, especially in the…
1. The central hypothesis of this study is that genetic polymorphisms in drug metabolising enzymes and regulators of enzyme expression may predispose to ATDH. We propose to evaluate the presence of genetic polymorphisms among TB patients in…
To assess the normal nasal microcirculation in vivo. Also, this research may lead to a better understanding of the pathophysological mechanisms operative in nasal dysfunction. It may help us to differentiate between aetiology of different disorders…
Incidence of familiar twinning in women that have double implantation after IVF/ICSI-treatment.
First: to determine the technical and logistical feasibility of measuring changes in myocardial perfusion and left ventricular function with gated 13N-NH3 PET before and during HD. Second: to compare changes in myocardial perfusion and left…
In this experiment we test two hypotheses regarding brain systems involved in alexithymia: (1) reduced activation of prefrontal areas during verbal processing of facial emotional expressions in working memory, and (2) compromised recruitment of…