3879 results
In this study, we will assess whether healthy and hypertensive subjects with high-normal serum CK display greater salt retention and vascular contractility, compared to those with low-normal serum CK.
To find out the fate of aneuploid blastomeres
The primary objective is to determine whether the DC/B-cell response to C. jejuni LOS differs in (ex-)patients with C. jejuni-related GBS compared to healthy controls. Secondly, we aim to define the variation in DC/B-cell response to C. jejuni LOS…
To obtain more information on peripheral muscle properties that can account for the reduced exercise capacity in patients with PPS compared to healthy subjects, and to develop an alternative method for determining aerobic exercise capacity in…
The primary aim of this study is to identify the muscles that are most critical to the abnormal standing posture, standing balance and gait in FSHD patients and to elucidate the most important mechanisms of falls. The ultimate goals are (1) to…
Our main aim is to describe the 24-h circadian rhythm of skin and core body temperature in people with SCI and examine whether changes in melatonin and/or cortisol relate to the altered circadian rhythm in core body temperature recently described in…
The primary objective in this study is to detect the presence of supra-spinal central sensitization in patients with chronic neck pain secondary to cervical facetal arthropathy. We aim to show this by comparing the pressure-pain thresholds (PPT; the…
The first aim of this study is to identify factors which predict an improvement of gastroesophageal reflux after gastric banding. The second aim is to assess the effect of gastric banding on gastroesophageal reflux after the operation.
To identify intraarticular parameters related to the initiation and course of development of articular cartilage lesions after knee trauma.
The major aim is to apply deep sequencing technology to obtain a detailed unbiased overview of the bacterial microbiome of human skin. This will be performed in healthy individuals, psoriasis patients and atopic dermatitis patients. Furthermore, we…
The main goal of this study is to examine the clinical applicability of the Monica AN24*, for the use of this device in the LUMC for prolonged CTG-registrations in high risk pregnancies and particularly in monitoring fetal cardiac arrhythmias. The…
The goal of the present study is to describe this unique sample on the basis of dossier analysis at the time of referral and reassess all individuals for follow up. VERPLAATST: The main objective of this study is to assess long-term outcome of…
The overall objective of this study is to assess to what extend different cognitive domains are affected by a recent TNA and which mechanism is responsible for this cognitive decline. We wanted to know whether the kind of TNA (focal, non-focal,…
1. Do body fatness and/or body fat distribution show a linear association withmicrovascular function in normal as well as IGT subjects?2. Is the effect of body composition on the microvasculature mediated by alteredadipokine profile, low-grade…
The primary objective of this study is to asses whether HIF signaling pathways show less activity in patients with preserved ejection fraction compared to patients with systolic dysfunction. Secondary objectives are to assess the relation between…
the aim of the current research project is to investigate the effect of the mirror box illusion on movement performance, neuromuscular activation and proprioception in children with SHCP. The following objectives are: to determine the effect of the…
1. To compare the effects of fasting on energy sensing machinery in muscle of obese vs normal weight subjects2. To compare neuronal activity in the brain in response to fasting in obese vs normal weight humans3. To compare the activity of the HPA…
We intend to study the effect of trastuzumab on the cardiac neuronal activity in patients with HER-2 positive breast cancer by using iodine-123 meta-iodobenzylguanidine (123I-MIBG) and cardiac imaging. 123I-MIBG, an analogue of the false…
The objective of the first part of the study is to assess whether circadian misalignment: - decreases energy expenditure and activity induced energy expenditure - alters substrate oxidation- alters feelings of hunger and satiety - alters food choice…
The lifespan of human neutrophils, eosinophils, basophils and monocytes under homeostatic conditions
The results of this study will lead to an improved insight in the lifecycle of these cells and our results will be of importance for more insight in chronic inflammatory diseases. For example, it will improve our ability to interpret the results…