265 results
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
Primary objective1.To determine the characteristics, frequency and severity of vascular, metabolic and hormonal side effects of angiogenesis inhibitors and EGFR inhibitors.Secondary objectives1.To investigate if steroid profile, indol profile,…
With this project we aim to clarify the differences in airway pathophysiology between asthmatics and healthy controls that underlie the prolonged survival of virus and the exaggerated inflammation in virus-induced exacerbations of asthma. We will…
The following research questions are formulated:A. Does exposure to cannabis (THC) result in an increased dopamine response in the striatum (as measured with PET)? And does cannabis use lead to an increase in psychotic experiences or symptoms?B. Do…
This study will investigate the relationship between autonomic nervous system function and pain in fibromyalgia, with a specific emphasis on awareness of bodily sensations, also refered to as interoceptive awareness, as a potential modulator of pain…
Study A: Show BP patients similar progression in brain volume change compared to schizophrenia patients. If so, can the progressive change in BP patients also be explained by genetic factors?Study B: Show BP patients and their non-bipolar cotwins…
Our hypothesis is: HBV interferes with the function of intrahepatic innate immune cells, especially NK cells. Since NK cells play a major role in anti-viral immunity and NK cells comprise a large proportion of the intrahepatic immune cells, we would…
Identify and further explore the structural brain alterations in ALS patients in comparison to healthy controls and to investigate the correlations of anatomical changes with clinical variables.
The objective of this study is to investigate the effects of replicated and theoretically interesting autism risk genes on brain anatomy in ASD. We will use psychiatric genetics and gene expression patterns to predict neuroimaging findings in ASD.
The objectives of this study are to gain new insights on [1] the cause of a higher clopidogrel resistance in DMII patients[2] the increased production of tissue factor in monocytes in DMII patients
The aim of this study is to investigate how often thymic hyperplasia is present in Graves' disease. Moreover we will investigate if thymic hyperplasia in Graves' disease is caused by stimulation of T cell development in the thymus.
1 : Will the intake of a liquid meal lead to insulin-induced microvascular dilatation in healthy subjects? 2: Does meal composition (high fat meal vs. high carb meal) play a role in the occurence of insulin-induced microvascular dilatation in…
Within WP6 of a EU Seventh Framework project, we will investigate associations between purinergic receptor SNPs and osteoporosis risk in humans. Genetic data from a fracture cohort in The Netherlands with high prevalence of osteoporosis will be…
The objective of the proposed research is to gain insight into the circumstances under which anxiety and avoidance behaviour can develop. More precisely, the goal of the current trial is to determine whether a genetic basis exists for the individual…
In a randomized controlled trial, the effects of DHCA and ACP during complex neonatal cardiac surgery on organ function and injury will be compared, especially focusing on cerebral damage and neurological outcome. The primary research question is…
The aims of this research proposal are to detect; 1) which early (degenerative) changes occur in bone, cartilage and menisci in patients with an acute complete ACL rupture, 2) at what point of time after the initial injury do these early changes…
Identification of genetic and biochemical riskfactors for CHD in patiente with chestpain. The identification of (genetic and biochemical) markers that determine the efficacy of a medical or invasive therapy in these patients.
Firstly, measurement of the impact of seizures in stroke patients by comparing quality of life, cognitive function, disability, handicap, and mood between stroke patients with and without seizures.Secondly, recording information on treatment of post…
1. to investigate early haemodynamic alterations and endothelial function in young prehypertensive medical students; 2. to examine the possbility to improve these haemodynamic changes after exposure to an endothelial dependent (salbutamol) and…
1) To demonstrate that the FcRn functions as a transporter and protector for vitreous IgG and monoclonals (Avastin, Lucentis) and show that monoclonal therapeutic antibodies are transported over the RPE via the FcRn. 2) To investigate if…