95 results
Main objectives: 1. Determine whether the POAG patients with low values of the blood mtDNA copy number have a low mtDNA copy number and low mitochondrial function in skin fibroblasts, using in vitro assays of mitochondrial function.2. Explore the…
Identification, segregation analysis, and functional characterization of genetic variants possibly causing rare bleeding disorders. The following questions will be answered:1) Can we identify (new) causal variants that explain the phenotype of…
To determine the role of dietary BCAA ingestion and omittance on MPS and insulin sensitivity
Main objectivesCohort study:To investigate the prognostic implications of skin sodium accumulation for CKD patients.Sodium excretion intervention study:To study the effect of increased renal sodium excretion, with and without aldosterone blockade,…
To assess the ability of MRI techniques to detect early stages of lipid accumulation in the liver of ASMD patients with the chronic visceral subtype compared to values of age-, sex- and BMI-matched healthy subjects.
Our primary objective is to assess the relation between itch and sustained attention in 7-11 year old children with atopic dermatitis (AD). Secondary objectives are to assess the relation between itch and task-oriented behavior, to assess whether…
By means of this study we want to determine how many victims of sexual violence, who seek help within 72 hours at the CSG Gelderland Zuid-Midden (CSG-GZM), have alcohol and/or drugs in their urine, voluntarily or involuntarily. To make it clear how…
The primary objective of this study is to obtain insight in how the light spectra may regulate eye growth and control emmetropization by studying the choroidal thickness in human eyes after exposure to monochromatic light conditions. Based on…
In this study, therefore, we aim to investigate how trained immunity is systemically regulated in SLE patients and how the degree of trained immunity affects disease activity and severity. A better understanding of these processes contributes to the…
We aim to collect skin and blood cells from two to three WitKoS patients, reprogram these cells into iPSCs and use the iPSCs for differentiation into neurons/neural organoids to study the molecular underpinnings of WitKoS.
To determine differences in brain activation and networks in alcohol responsive essential tremor versus alcohol resistant essential tremor.
Primary Objective: 1. Objectify and quantify exercise intolerance in LcFAOD patients. 2. Determine the relationship between the measured exercise intolerance and patient-reported symptoms, daily life functioning , as well as known markers of disease…
Objectives of phase 7 of the ABCD-study are:(i) to follow-up on growth trajectories during childhood/adolescence and identify lifestyle and environmental factors that influence thesetrajectories;(ii) to follow-up on cardiometabolic health during…
To determine the effects of tissue-specific (adipose tissue or muscle) vs global (combined) IR on hepatic triglyceride biosynthesis in humans. To determine differential effects of an acute exercise intervention on hepatic triglyceride biosynthesis…
The aim of this study is to investigate to what extent biomarkers are related to the development of ventricular arrhythmias, in order to improve the indication for ICD therapy.
The main objective of this study is to determine whether prolonged exercise training in the afternoon (15:00-17:00 PM) differs from exercise training in the morning (07:00-09:00 AM) in improving nocturnal glucose levels in individuals with pre-…
To identify causal socio-genetics longevity mechanisms protecting from (multi)morbidity in humans:1. The primary objective is to disentangle novel rare-, and structural gene variants that can explain longevity and protection from (multi)morbidity in…
Primary objectives: 1. To assess the difference in bioprosthetic leaflet 18F-NaF PET activity, as an early marker of transcatheter valve degeneration, between patients with vs. without SCLT at five years after TAVI.2. To assess the difference in…
To investigate the effect of daily intake of 350 milligrams of magnesium citrate oral supplementation over a period of six months on calciprotein particle maturation time (T50) in serum, a measure of calcification propensity, and on vascular…
To study if acute stress has a significant effect on executive functioning scores in healthy military personnel.