1889 results
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
Primary Objective: To determine the accumulation of AGEs in the skin and serum of pregnant women with DM1, DM2 or GDM, in comparison to healthy pregnant women and non-pregnant women with DM1 or DM2 and to determine the accumulation of AGEs in the…
First objective; to document the existence and to categorize vocal fold pathology after short term intubation and to study voice related patient complaints after short term intubation. Second and third objective; to study the pattern/type of injury…
Discover diagnostic biomarkers for disease severity. Increase the insight in the epidemiology of viral infections in the primary, secondary and tertiary care facilities and in the pathogenesis of and immunological response against viral infections.
To obtain more information about the effects of capsaicin and cinnamaldehyde on the intestine, these substances will be infused directly in the duodenum. Hereafter, the permeability of the intestine, gallbladder motility and the effects on satiety…
In the current study this hypothesis will be tested by examining whether blood serotonin levels, which are indicative of central serotonin levels, differ between infatuated and non-infatuated individuals. Furthermore, it will be investigated whether…
Aim is to establish the relation between plasma and tissue AGE levels and the severity of diastolic/vascular dysfunction and its relation with symptoms in patients with type 2 DM with and without CHF, and in patients with CHF without DM. Primary…
This research project aims to investigate the interaction between systemic immune cells and cells from the glandular tissue of patients with Sjögren's syndrome and sicca syndrome. We hope to obtain more insight in the cause and persistence of…
To assess differences in brain activation during the AA task in participants with SAD.
The following research questions are formulated:A. Does exposure to cannabis (THC) result in an increased dopamine response in the striatum (as measured with PET)? And does cannabis use lead to an increase in psychotic experiences or symptoms?B. Do…
This study will investigate the relationship between autonomic nervous system function and pain in fibromyalgia, with a specific emphasis on awareness of bodily sensations, also refered to as interoceptive awareness, as a potential modulator of pain…
Study A: Show BP patients similar progression in brain volume change compared to schizophrenia patients. If so, can the progressive change in BP patients also be explained by genetic factors?Study B: Show BP patients and their non-bipolar cotwins…
Our hypothesis is: HBV interferes with the function of intrahepatic innate immune cells, especially NK cells. Since NK cells play a major role in anti-viral immunity and NK cells comprise a large proportion of the intrahepatic immune cells, we would…
In this project the expression, glycosylation and sialylation of mucins will be determined in tissue specimens of salivary gland tumors and in parallel, in the saliva of patients with a salivary gland tumor to determine whether altered mucin…
Primary Objective: 1) To investigate if the intestinal permeability acutely increases during physical activity (submaximal cycle ergometry or ADL test) in clinically stable patients with moderate to severe COPD; 2) To investigate if the intestinal…
To identify an AAA associated genes by a functional candidate gene approach.The identification of an AAA associated gene will have several impacts on this high prevalent disease:1. It will improve our understanding of the molecular pathways involved…
In this study we aim to validate changes in the pulse pressure after controlled volume loss during blood donation in spontaneously breathing subjects. This validation will contribute to the development of a standardized manner in which the Nexfin…
Identify and further explore the structural brain alterations in ALS patients in comparison to healthy controls and to investigate the correlations of anatomical changes with clinical variables.
The aims of this pilot study are to describe the nutritional status of a well-defined group of Dutch RTT girls with complete clinical, molecular and neurophysiological work-up (full description is presented in the section *study population*) and to…
The first objective of this study is to assess whether emotional responsiveness in PD patients is different from that of matched healthy controls and whether emotional responsiveness in PD patients with apathy is different from that in PD patients…