29 results
The proposed study has 2 main aims: 1) Understanding the complex interplay of determinants of parenting and examining how specific parenting styles explain associations between parent characteristics (such as personality or mental and physical (ill…
Primary objective: 1. To identify the components in human milk (e.g. nutrients, oligosaccharides, fatty acids and (pathogen specific) immunoglobulins) that have a protective effect against respiratory tract infections during the first year of life.…
Primary objective: To improve outcome prediction in sFGR by developing a prediction model at the time of sFGR diagnosis and by evaluating specific ultrasound parameters throughout the pregnancy. Secondary objectives: - To increase our knowledge of…
Research question: Is maternal microbiome dysbiosis in MOB an underlying mechanism in the pathophysiology of adverse maternal pregnancy and offspring outcome?Objectives: Analyse the differences between the gut and vaginal microbiome, maternal and…
To investigate the relationship between body composition and parenteral nutrition in children with intestinal failure at 6 months corrected age. The ultimate goil of this study is to optimize the treatment of children with intestinal failure by…
The main objective is to pinpoint the biological pathways that set long-term risk of CVD and NDI when epigenetically disturbed during fetal development by (1) establishing a longitudinal cohort of MC twins, (2) defining epigenetic alterations…
To evaluate the performance of a *genotype first approach* (WES-based panel analysis) in diagnostics of genetic predisposition in children with cancer or neoplasms, compared to the current *phenotype first approach* (standard of care). In particular…
Estimate key transmission parameters of SARS-CoV-2 in Europe from observing within household virus spread and seroconversion of household members, and to characterize the views and experiences of households regarding perceptions, practices regarding…
The primary objectives of the NO GBS study part 1 are to: - determine the clinical characteristics and outcome, and the prevalence of risk factors used by Dutch guidelines for risk assessment in GBS and E. coli meningitis and sepsis cases aged 0-3…
The main objective of the study is to dissect the genetic and stress-based mechanisms on the development of pediatric heart failure in congenital heart disease (ConHD) with the use of induced pluripotent stem cell-derived cardiomycoytes (iPSC-CMs).…
The MyKids study is a biological study towards the molecular profiling of pediatric NRSTS, the development of NRSTS tumoroid cultures, the establishment of liquid biopsy biomarkers and the molecular profiling of post-treatment tissue samples. The…
The SILVER study aims to give insight into the half-life of maternally acquired antibodies in preterms and the foetus to mother transfer function. These findings have implications for understanding infectious disease susceptibility, vaccine…
To establish a functional working protocol to analyze, characterize and determine the microbiome (including the virome) and its metabolome of the placenta, neonate and periconceptional semen and vaginal/cervical/uterine/rectal environment.
To validate biomarkers that are associated with severe RSV infection and respiratory sequelae.
Brain tumors: Characterize and quantify changes in immune parameters during disease in patients with a CNS malignancyAML: Characterize and quantify changes in immune parameters and immunotherapeutic targets during disease in pediatric patients with…
To quantify the strength and direction of interactions between important respiratory virus infections in young children
Primary objective: To obtain a detailed immunological profile of children presenting to Dutch hospitals with acute SARS-CoV-2 infection or with a SARS-CoV-2 related post-infectious inflammatory syndrome. Secondary objectives: (1) To correlate the…
To analyze the effect of early (12 weeks corrected age) versus late (17 weeks corrected age) introduction of complementary feeding on obesity at the age of 2 years in preterm infants. Furthermore, the effect of complementary feeding on body…
A pilot study to understand the transmission dynamics of RSV in households and potential reduction of viral transmission.
The objectives of the study are to:A. Determine the effects of music therapy during skin-breaking procedures on the pain response in infants admitted to a NICU or HC ward.B. Determine the effects of music therapy during skin-breaking procedures on…