73 results
Mainstreaming of germline genetic tests in regular healthcare is feasible for healthcare professionals and acceptable for both patients and healthcare professionals
Most patients undergoing spine surgery with pedicle screw instrumentation will experience insufficient pain relief in the first three days after surgery, whereafter postoperative pain can be managed with conventional, non-opioid analgesics in most…
Objective The objective of this study is to assess which risk scoring model is most cost-effective for the discrimination between benign and malignant ovarian tumors that guides referral decisions for women with ovarian tumors in the Netherlands…
"The main objective of this trial is to assess long-term performance and obtain real-world experience with the bi-hormonal fully closed loop system (Inreda AP®)"
To determine: 1) How neuropsychiatrich problems change over time during the first year after stroke; 2) Which determinants are related to the course of neuropsychiatric problems over time during the first year after stroke; 3) What are the…
Measuring tFUS-dependent changes in behaviour (in our target tasks) when targeting deep brain regions [Behavioral Objective]
To explore, whether markers of mitochondrial dysfunction measured in isolated PBMCs or immune cell subpopulations differ between subjects with mitochondrial disorders and cardiomyopathy and healthy volunteers.
Phase 1: Assess reliability of advanced respiratory muscle ultrasound imaging in healthy subjects and congenital myopathies/muscular dystrophies. Phase 2: assess two year follow-up of respiratory function using advanced respiratory muscle ultrasound…
Primary Objective: Does DBS result in cognitive changes in patients with OCD on the long term? Secondary Objective(s): Does DBS result in personality changes in patients with OCD on the long term?Are certain cognitive profiles associated with…
To assess whether co-ingesting keto-analogues of branched-chain AAs along with protein during HD can attenuate HD-initiated muscle catabolism.
The aim of this study is to investigate the concept of fear of progression among advanced incurable cancer patients onongoing systemic treatment.
The primary goal is to compare functional (language) areas in the brain found by preoperative fMRI, to those found during intraoperative ESM (electrical stimulation mapping) and fUS (functional ultrasound) during awake craniotomies, to see whether…
The primary objective is to determine if there is a difference in autonomic function between patients with Alzheimer*s disease (MCI and AD) and a matched control group. The secondary objectives will be explorative and aimed to investigate…
The objective of this exploratory trial is to explore the acute and chronic effects of daily olive leaf extract supplementation on muscle energy and fatigue in healthy male adults
To study the effect of individual control of the light on thermal comfort
To examine the thermophysiological responses to prolonged exercise in hot and humid environmental conditions in patients with a history of exertional heat stroke or malignant hyperthermia susceptibility and compare the thermophysiological responses…
The objective of this proof-of-concept study is to investigate (differences in) small intestine microbiota and postprandial glycemic responses.
Obtain phased-contrast 4D flow MRI scans in 20 healthy volunteers to quantify local blood flow in the thoracic and abdominal aorta and extract boundary conditions for future in vitro studies. Furthermore, the 3D geometry of the vessels within…
To compare the post-prandial muscle protein synthetic response following ingestion of a whole-food meal containing meat versus the ingestion of a meal containing only plant-based protein sources in vivo in healthy, older men and women.
The purpose of this study is to evaluate the user experience of InPen* with InPen Diabetes Management App and Guardian * 4 system in adult patients with type 1 diabetes for the design of a future pivotal study.