2170 results
The current study will evaluate systematically the efficacy and cost-effectiveness of two internet-based CBT/relaxation programs (one guided, the other self-managed) in reducing the severity of menopausal symptoms and improving copings skills with…
Primary ObjectivesTo evaluate the IRE intensity/color mitigation effect of a single administration of Brimonidine tartrate in comparison with a vehicle gel (placebo).Secondary ObjectiveTo evaluate the IRE intensity/color mitigation effect of a…
In the current study, we will 1) evaluate the usefulness and reliability of this new device, and 2) evaluate whether the anatomic site used will impact the measured CPM effect.
Primary objective:- To assess the safety of concizumab given as multiple s.c. doses to subjects with haemophilia ASecondary objectives:- To assess pharmacokinetics of concizumab in subjects with haemophilia A after multiple s.c. doses- To assess…
Primary Objective: The association between the functional improvement (change in VO2 max) and DSE parameters will be determined. In this way the diagnostic characteristics of DSE will be investigated.Secondary Objective(s): The influence of the…
Hypothesis #1 efficacyWe hypothesize that a quick onset and a good adjustability of analgesia can be achieved with inhaled ketamine.Hypothesis #2 safetyInhalation of nebulized ketamine might lead to a fast onset of analgesia, with limited adverse…
Both the Supera and the Absolute Pro Stent System are self-expandable stents that are frequently used in regular clinic practice in patients with obstructive vascular disease. Results of both stent systems have been evaluated in several studies and…
Our aims are to analyse whether there is a specific HLA allele or allelic combination associated with susceptibility to LGI1 encephalitis, and to perform a pilot study with HLA subtyping in patients with encephalitis due to antibodies to Caspr2,…
The main objective of this study is to assess the effect of visual cues (provided by smart glasses) in the form of visual lines on the floor on walking performance and occurrence of FOG in comparison to walking without visual cues and walking with…
Objective: To assess the impact of zirconium-89-girentuximab PET/CT on clinical decision making in patients suspected of primary, recurrent or metastatic clear cell renal cell carcinoma.
The study will include a total of 250 physiotherapists and 1000 patients. The aims of this study are: (1) to perform *big data* analyses on the raw sensor data, in relation to concurrently acquired clinical data in these patients (limited version of…
In a pilot study patients scheduled for a regular implantation of a (or undergoing an upgrade to a) CRT-device will also be implanted with a heart monitor in the pulmonary artery. This implantable heart monitor (IHM) will collect data during…
The aim of this study is to gain insight into speech discrimination abilities of teenagers, by the use of the online speech-in-noise test, Earcheck. The main objective is to explore the relation of SRT scores with age, gender, and education level.…
Primary: To compare postprandial plasma amino acid concentrations after ingestion of a fixed amount of protein from different dairy products in elderly subjectsSecondary: To determine effects of a fixed amount of protein from different dairy…
Investigate whether differences of the thermostat set point between the sexes might be responsible for BAT differences between men and women. Secondly, we investigate whether women have a different glucose uptake during cold exposure than men.
To study if it is feasible to conduct such a investigation in the future, I first want to search for 35 volunteers who are willing to follow the paleo diet during four weeks and the Dutch Consensus Diet during four weeks. After both periods of four…
The purpose of this studie is to evaluate the bioequivalence of canagliflozin.
To establish the role of renal sympathetic modulation on renal blood flow, metabolism and oxygenation we propose three closely related series of experiments.Group 1: Sympathoactivation in healthy humans 12 healthy volunteers will undergo a graded…
To assess the effect of the setting of two types of anaesthesia (spinal versus general anaesthesia) on outcomes of remedial surgery (i.e. quality of life, patient satisfaction and pain relief) in patients diagnosed with chronic inguinodynia.
In the current pilot-study, we will focus on demonstrating whether personalisation improves compliance with advice on diet and physical activity patterns in a population of community-dwelling seniors. This advice will be based on personal preference…