2170 results
assess the contraceptive efficacy and safety of the etonogestrel (ENG) 125 + 17*-estradiol (E2) 300 µg /day vaginal ring
The main objective of this study is to answer the following question: What is the prevalence of child maltreatment amongst high school students in the Netherlands. Secondary objectives are the determination of the prevalence of subtypes of child…
To perform sensory testing in patients who have undergone a cervical percutaneous cordotomy. The sensory testing include 'quantitative sensory testing' according to the *the German Research Network on Neuropathic Pain* protocol and a *…
Primary Objective: In the CORAL study we want to determine whether increasing the inoculation dose of diarrhoeagenic E. coli to 5*10^10 CFU and addition of a second challenge 1*10^10 CFU will result in an increased effect-size and duration of…
RESEARCH QUESTION(S): Can in vivo reflectance confocal microscopy (RCM) correctly identify the subtype of basal cellcarcinoma (BCC)?Primary Objective: To study whether in vivo reflectance confocal microscopy (RCM) can correctly identify the subtype…
The primary objective of this study is to assess how selective attention to different food characteristics (calories, taste intensity and pleasantness) affects brain responses during tasting. Secondary objectives are to assess (1) whether taste…
The main objective of the study is to evaluate the efficacy of the *Blended Coping Cat* program in reducing anxiety levels in children diagnosed with anxiety disorders and possible ADHD, ASD, mild intellectual disability or borderline intellectual…
The study is designed to clinically demonstrate device acute safety (Primary Endpoint) along with longer FU device safety and effectiveness evaluation (Secondary Endpoint).The main objectives of the study areU :1) Evaluate the Acute safety of the…
(1) To phenotype chronic low back pain patients in terms of endogenous modulation of pain, central sensitization/facilitation, and the presence of a neuropathic pain component;(2) To assess the effect of a three-month treatment with tapentadol on…
The aim of this study is to evaluate the endoscopic removal of early Barrett*s neoplasia and early squamous esophageal neoplasia with assistance of a modified esophageal overtube, using standard ESD techniques
To determine the efficacy and safety of MEDI4736 evaluated as a single agent or in combination with tremelimumab in patients with metastatic pancreatic ductal adenocarcinoma (PDAC) whose disease has progressed on 5-FU-containing or gemcitabine-…
Primary objective:•To assess the effect of multiple dose daclatasvir (60mg QD) on the pharmacokinetics (AUC, Cmax, Ctrough, CLr) of multiple dose metformin (1,000mg BID) by intra-subject comparison, in healthy subjects.Secondary objective:•To assess…
Primary objective of the study:- The primary objective for this study is to determine the prognostic characteristics for BPAR in the first 3 months after transplantation, as assessed in the lymphocyte composition of the lymph node in immunologically…
Primary:To evaluate whether patients with severe eosinophilic asthma who have received longterm treatment with mepolizumab (at least 3 years) need to maintain treatment with mepolizumab to continue to receive benefit.Secondary:To assess the safety…
Cervical split laminectomy vs conventional cervical laminectomy for treatment of cervical myelopathy
The purpose of this study is to evaluate the long-term results of the split laminectomy and compare these resultsit to the long-term results of the conventional laminectomy. The prevalence of kyphosis and segmental instability is being investigated…
The aim of this study is to discover a new set of parameters to define the electropathological substrate by integrating cardiac magnetic resonance imaging (CMR) and non-invasive electrocardiographic imaging (ECGI) characteristics. In the future,…
A new method, implemented in the I-Space Virtual Reality application, will be tested on its reproducibility and validity. It will be used to describe fetal movement patterns. This new method can improve the rapidity of fetal movement studies and…
The aim of this study is firstly to investigate the effect of repeated exposure to vegetables or fruit at the start of weaning on short and long term vegetable intake. A second objective is , to investigate the effect of a responsive feeding…
This study aims to provide evidence for the notion that reduction of spasticity by bilateral BTX injections in the hip adductor group followed by self-administered stretching exercises and agility training improves lateral stepping and gait…
Deulevodopa in combination with carbidopa is a combination in development for the treatment of patients with Parkinson*s disease.The effects of deulevodopa taken with carbidopa have not yet been tested in humans, and there are no available clinical…