2170 results
The hypothesis is that SMBG underestimates the number of hyperglycaemic episodes in women with gestational diabetes mellitus. The aim of this study is to evaluate if CGMS detects hyperglycaemia when the standard SMBG day curve is normal.
Primary objective:To evaluate the single- and multiple-dose safety and pharmacokinetics of CNM-Au8 upon oral administration of CNM-Au8 to healthy adult male and female subjects.Secondary objective:Exploreing the immune-modulating effects of CNM-Au8…
To investigate whether the dose of biologics can be reduced in patients with psoriasis with stable disease: is dose reduction non-inferior to the current practice regarding clinical effectiveness? Secondary aims are: to investigate what influence…
The aim of this study is to evaluate the efficacy, safety, compliance and tolerability of 15 years of pravastatin therapy initiated during childhood in young adult FH patients.
To assess the PD, PK and safety of the Zoreline 10.8 mg goserelin subcutaneous (SC) implant.
Research question:1. Do patients exhibit disturbances of sleep duration or circadian locomotor rhythmicity before surgery? 2. Do these variables change after surgery?
In the current study we will apply the Elfitor and collect its derived parameters during nociceptive stimulation in healthy volunteers without and with the administration of a low-dose opioid analgesic. Our study aim is to assess whether the various…
To assess the benefits and harms of SUP with PPI in adult, critically ill patients in the ICU.
The primary objective of this study is to develop an ultrasound-based activity index with appropriate cut-off values that can be used as a point-of-care test for the assessment of mucosal disease activity in UC patients. Secondary objectives of this…
The influence of the initial vitamin D status on the fracture consolidation will be studied. These study results might give rise to a randomised controles trial with vitamin D supplementation in order to investigate the effect of supplementation on…
Primary Objective• To educate students about the full life cycle of clinical trials including study set-up, design, execution, analysis and reporting• To explore the influence of CYP2D6 polymorphism on the pharmacodynamics and pharmacokinetics of…
Primary objectiveTo evaluate the long-term safety of 10-, 10-, 20-mg/kg ataluren in patients with nonsense mutation cystic fibrosis (nmCF), who previously participated in pivotal study PTC124-GD-021-CF, as determined by adverse events and laboratory…
Primary Objective: To determine the effect of omega-3 PUFAs on exercise performance. Secondary Objective: To determine the effect of omega-3 polyunsaturated fatty acids supplementation on performance determining variables, such as VO2max, VO2 at the…
Primary objective:To compare the effect of multiple dose atazanavir/cobicistat on the multiple dose phar-macokinetics of daclatasvir with the effect of atazanavir/ritonavir on the multiple dose of daclatasvir by intra-subject comparison in healthy…
To characterize the interaction between the genetic background, the microbiome, and the immune responses in patients with diabetes type 1, both cross-sectional and over time, and to identify the disturbances in this interaction.
Primary:• To evaluate the safety of RejuvenAir Cryospray therapy to treat symptomatic chronic bronchitis patients with airflow restrictions• To evaluate the feasibility of the planned liquid nitrogen cryospray treatment.Secondary:• To evaluate…
This study investigates interpretation bias on pain- and health related information with adolescents and young adults between the age of 13-30 years old.
We purpose to determine whether the international normative values are applicable in our center in 10 healthy participants. Furthermore, CCM will be introduced as additional diagnostic tool in patients with (possible) SFN.
Cognition in patients with Juvenile Myoclonus Epilepsy and their first degree healthy family members
Key Question: What is the level of cognitive performance in healthy siblings of juvenile myoclonic epilepsy patients compared to that of patients with juvenile myoclonic epilepsy?