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A prospective, multicenter, randomized, open-label, active-controlled, phase III study to compare efficacy and safety of masitinib to imatinib at 400 or 600 mg in treatment of patients with gastro-intestinal stromal tumour in first line medical treatment

Safety and efficacy objectives:The objective is to compare the safety and efficacy of masitinib at 6 of 7.5 mg/kg/day to imatinib at 400 or 600 mg, in patients with gastro-intestinal stromal tumour in first line medical treatment.

Pharmacokinetic study to assess the bioavailability of phenolics from an olive leaf extract

The objective of the study is to obtain information on the bioavailability and pharmacokinetics of the phenolics present in an olive leaf extract (Bonolive®, dose 250 mg), standardized on 40% oleuropein, and to identify the composition of the…

Randomized double blind multi-centre study of the effects on low-dose pegvisomant treatment in acromegalic subjects in whom the IGF1 levels has been normalized by long-acting somatostatin analogues

Primary Study Objective:To assess the efficacy and safety of the co-administration of low-dose pegvisomant (40 mg, administered via subcutaneous injection given once a week) and long-acting somatostatin analogs (administered once monthly) on the…

Chronic fatigue and return to work in cancer survivors

The primary objectives are:- to identify predictive factors for fatigue in cancer survivors on long-term sick leave. - to develop a prognostic instrument by which insurance physicians can assess future functional abilities, related to the work…

The relation between neurodegeneration and other pathology in multiple sclerosis: an in vivo MRI study

The aim of this MRI study is to understand how neurodegeneration in MS (in vivo) is related to other facets of MS pathology, i.e. inflammatory (T2) lesions, black hole (T1) lesions, cortical lesions and damage of the normal appearing brain tissue.…

Electrochemotherapy in head and neck cancer patients

The primary objective of this study is to determine the response rate of electrochemotherapy in head and neck cancer. Secondary objectives are to monitor local and systemic side effects and adverse events and to determine quality of life before and…

Coagulation effects of mild therapeutic hypothermia in post cardiac arrest patients.

We aim to observe in whole blood at patients core temperature and normotemperature how mild therapeutic hypothermia affects coagulation and in particular fibrinogen, in post cardiac arrest patients.

Effect of bile drainage and rifampicin, a pregnane X receptor agonist, on clinical and biochemical recovery of patients with obstructive cholestasis

To study the effect of alleviation of obstructive cholestasis by biliary drainage with or without rifampicin on serum bilirubin levels, quality of life, itch intensity, and serum and/or biliary bile salt, ATX, LPA, FGF-19 and biliary HCO3- levels in…

Genetics of Hirschsprung's disease

Idenification of new Hirschsprung's disease associated genes.

Elderly patients suspected of cognitive decline by family physicians; a cluster randomized controlled trial to improve the diagnostic and care process

To evaluate the feasibility and (cost) effectiveness of an intervention to improve the quality of dementia care and the wellbeing of home dwelling persons with dementia and their main informal caregiver.

Randomised controlled trial to evaluate the effects of tele-monitoring weight in oncology and COPD patients.

The primary objective of this study is to investigate if monitoring weight by tele-monitoring and its procedure in oncology and COPD patients results in less weight loss (or in weight gain), compared to the control group.The secondary objective of…

Role of flow cytometry in the assessment of restoration of hematopoiesis during standard Exjade® treatment in patients with low- intermediate I risk myelodysplastisc syndromes, a pilot study

- Primary objective:To evaluate the flow cytometric characteristics of the bone marrow compartment before and during treatment with Exjade® in low and intermediate-I risk myelodysplastic syndromes.- Secondary objectives:To correlate the flow…

A study on the influence of dynamic light on sleep and circadian rhythm, in long-stay patients on a haematology ward

To evaluate the influence of dynamic light on the disturbance of the rest-activity rhythm of patients admitted to the haematology ward of the Erasmus MC- Daniel den Hoed Cancer Centre.The results of the study can possibly be used in the future…

Internet-based treatment of depressive symptoms in patients with tumors inside or outside of the central nervous system.

The primary study objectives are: (1) to determine whether an internet-based guided self-help intervention is effective in reducing symptoms of depression in glioma patients; (2) to determine the impact of the intervention on the HRQOL of both…

Effects of High intensity Interval Training on CENTRAL hemodynamics at rest and during exercise

The main objectives of this study are to evaluate the effects of HIT in CHF patients on cardiac output at rest assessed with cardiac magnetic resonance imaging(cMRI), and to investigate the relation between changes in resting cardiac output and…

PRognostic hEModynamIc profiling in the acUte ill eMergency department patient: PREMIUM registry

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ReStoRe: Clinical and cost-effectiveness of self-management strategies in stroke patients and their partners

The purpose of this study is to investigate the clinical effectiveness of a self management group intervention for stroke patients with social reintegration problems and their partners compared to a control group education intervention. The main…

Releasing the brakes on CD8+ T cells in the melanoma sentinel lymph node by pre-operative local administration of low-dose anti-CTLA-4 (tremelimumab)

1) To determine clinical safety and tolerability of local i.d. administration of a single dose of tremelimumab in clinical stage II melanoma patients scheduled to undergo a SLN procedure. 2) To ascertain the immunological effects of local i.d.…

The Effect of Gaucher Disease on Bone Cells

This will be a pilot study that aims to gain insight into the effect of Gaucher disease on bone metabolism. For this purpose we formulated the following research questions:What is the effect of inflammatory factors in the serum of patients with…

INCH-trial: A multicenter randomized controlled trial comparing the efficacy of conventional open surgery and laparoscopic surgery for incisional-hernia repair.

The main goal of the trial is to establish whether laparoscopic incisional hernia repair is superior to conventional open incisional hernia repair in terms of cost-effectiveness. This is measured through length of hospital stay and quality of life.…