538 results
The study should determine whether non-invasive continuous blood pressure values are comparable to intermittant oscillometric blood pressure determinations.
Feasibility study: The potential use of intraoperative, ICG based, fluorescence imaging of LN*s during CRC lymphadenectomy.
Primary research questions: 1. Is there a difference in effectiveness of clozapine treatment compared to olanzapine treatment in the reduction of substance use disorders of patients with schizophrenia and related psychotic disorders? 2. What is the…
The primary objective of the present study is to increase our insight in the neural processing in pre-lingually deaf and implanted patients, regarding the prediction and explanation of postoperative differences in performance within this specific…
Phase I- To characterize the safety and tolerability and determine the maximum tolerated dose of daily RAD001 in combination with daily sorafenibPhase II- To estimate the hazard ratio of the treatment effect as measure of anti-tumor activity of the…
Study goal is to answer the following question:Is there an effect of interactive education with a web-application on patient satisfaction for patients undergoing a colonic resection?Sub-questions are:1. Do patients with a higher education level have…
This hypothesis will be challenged in five objectives:1. To check the factorial validity of two cognitive styles - weak central coherence; poor cognitive shifting - in patients with MR and ASS.2. To assess the specificity of the association between…
- To determine physical fitness in children with a congenital heart disease (ventricular septum defect, atrium septum defect, tetralogy of Fallot, transposition of large arteries and patients after a (modified) Fontan-operation) and to compare…
In this study we will examine whether inhaled salmeterol inhibits house dust mite allergen-induced lung inflammation in mild asthmatics that are on maintenance treatment with low dose inhaled corticosteroids. If so, salmeterol may prove useful as…
Primary objective: to investigate the day-to-day shape variation of the CTV in rectal cancer patients in order to determine adequate PTV margins for radiotherapy treatment.Secondary objectives: to investigate the influence of bladder and rectal…
1. Gaining insight in the phenotypical differences between metabolically healthy versus metabolically unhealthy obese female subjects2. investigating the role of the dopaminergic system and the hypothalamus in glucose and lipid metabolism
How does the sets of brain regions of the pMNS interact to enable us to grasp so intuitively what is going on in other individuals?The present projects aims at investigating the connectivity between the brain areas identifyed as part of the human…
Primary objective: To study the influence of repeated oral administration of ketoconazole, a potent CYP3A4 inhibitor, in a therapeutic dose on the plasma pharmacokinetics (PK) of eribulin administered via intravenous (IV) infusion.Secondary…
Our overall aim is to obtain a better understanding of brain network damage in dementia patients. We propose a research project with two key objectives:1. Develop improved methods to describe functional brain network damage2. Relate network damage…
To investigate the relation between premature cardiovascular disease and glycocalyx perturbation
The primary objective is to investigate the effects of intravenous administration of C1INH in human volunteers on cytokine release (TNFa) during endotoxemia. The secondary objective is to determine the effect of administration of C1 INH on…
The primary objective is to establish whether patients are at increased risk for VT/VF during inflammation. The secondary objective is to establish whether increased risk during inflammation is mediated by hyperthermia and inflammatory cytokines.…
Primary goal is studying the safety and feasibility of administering chemotherapy (cisplatin and pemetrexed) after of before treatment with stereotactic radiotherapy by observing and recording toxicity during and after the study.
Primary: To observe the correlation between ABCB1 polymorphisms in Exons 13, 22 and 27 and the clearance of sunitinib at steady state. Secondary: - To determine whether ABCB1 genotype correlates with toxicity-adjusted dose of sunitinib - To…
To determine toxicity of selective pulmonary artery perfusion (SPAP) for the treatment of non small cell lung cancer.