2072 results
Primary objectives: To evaluate the long-term safety and tolerability of IV administered bapineuzumab in subjects with AD.Secundary objectives: Efficacy. To explore the long-term efficacy of IV administered bapineuzumab in subjects with AD, using…
How does motor fatigue influence the cognitive functioning of patients with MS and how does this interaction compare to that in healthy controls?
The objective of this study is to compare the overall survival of patients with prostate cancer who are no longer responding to hormone therapy (castration resistant) and who have not yet received chemotherapy live longer (overall survival) when…
Is the application of CryoSeal (CS) in primary total knee replacement surgery beneficial for the patient with respect to a faster track and improved postoperative rehabilitation. The beneficial effect may be due to quicker functional knee…
The primary objective of this study is to compare the overall survival (OS) of ramucirumab DP administered in combination with docetaxel versus docetaxel with placebo as therapy for patients with Stage IV non-small cell lung cancer (NSCLC) who have…
Objective: Primarily, the objective of this study is to assess the role of serotonergic and dopaminergic polymorphisms in fear conditioning. Secondary, we will investigate additional cannabinergic and corticotropinergic polymorphisms in fear-…
This project examines their relative contribution using pupil dilatation and concentration cortisol and alpha amylase in saliva as objective measures of mental effort and questionnaires. Young and elderly normally hearing and hearing impaired…
The primary objective of the study is to determine if the treatment of AMG 479 at 12 mg/kg and/or 20 mg/kg in combination with gemcitabine improves overall survival as compared with placebo in combination with gemcitabine in subjects with metastatic…
Primary ObjectivesIn patients with primary hypercholesterolemia and high cardiovascular risk with LDL-C >=100 mg/dL (2.59 mmol/L) and <=160 mg/dL (4.14 mmol/L), to evaluate:1)at the end of Phase I, the additional LDL-C percentage…
To compare the effectiveness of the tocolytic agents Nifedipine (a calcium channel blocking agent) versus Atosiban (an oxytocin receptor antagonist) in the improvement of neonatal outcome in women with threatened preterm labour (25-34 weeks…
Primary Objective:• To determine if orteronel plus prednisone improves overall survival (OS)Key Secondary Objectives: • To determine if orteronel plus prednisone improves radiographic progression-free survival (rPFS)• To determine if orteronel plus…
To optimize the management of non-chronic shoulder pain in primary care by the introduction of ultrasound as a diagnostic triage tool. The following research questions will be addressed:1. What are the effects of diagnostic ultrasound and its…
To improve symptomatology in severe chronic failure patients.
To further develop the dignity model in the nursing home setting by assessing which factors are especially relevant to dignity in this setting. The specific objective of this substudy is to develop a valid and reliable measurement instrument to…
To generate the information required to produce accurate and dynamic computational models of the human foot and ankle for the purposes of orthotic development.
Verification of number of mode switches, Verification of undersensing of AFor other ATAs. Incidence of mode switches due to FFRW oversensing using Accent pacemaker in the most sensitive sensing setting(s)using the Optisense vrs Tendril lead
With the aim to restrict inappropriate FFP transfusions to critically ill patients, a randomized clinical trial will be conducted in a subgoup of ICU patients undergoing an invasive procedure. The objective is to assess the effectiveness and costs…
The primary aim of our study is to evaluate safety and toxicity of ex vivo-expanded NK cell infusions following a non-myeloablative conditioning regimen in elderly AML patients who are no candidates for allogeneic SCT. Moreover there is also a…
Primary: Effectivity. Secundary: Effectivity (questionnaires, progression, surgery), safety and tolerability.
Overall aim of the study is to investigate which decision-making models for patient participation are used in practice in end-of-life decision-making and how appropriate are these models for different patient groups.Secondary Objective(s): 1. In…