23 results
The test product supports normal physical growth in healthy term infants
This study has been transitioned to CTIS with ID 2024-514073-22-01 check the CTIS register for the current data. To investigate differences in coagulation between (Omniplasma) and FFP in paediatric cardiac patients, who are undergoing cardiac…
This study has been transitioned to CTIS with ID 2023-504593-38-00 check the CTIS register for the current data. The aim of this trial is to infuse multiple doses of human 1st trimester liver-derived MSC for the treatment of severe OI to determine…
Primary objective is assessment of the pharmacokinetic profile of MPD in pregnancy. Secondary objectives are the safety and efficacy of any use of MPD during pregnancy.
This study's first objective is to assess lung mechanics (measured with FOT) in mechanically ventilated infants, in the clinical practice of the NICU, with intermittent measurements during the entire period of mechanical ventilation. The FOT…
To quantify the strength and direction of interactions between important respiratory virus infections in young children
The aim of the study is to collect video recordings which will be used retrospectively internally at Philips to test whether an algorithm can be used to measure the behavior and physiology of babies by using a camera and/or wearable. Development of…
Brain tumors: Characterize and quantify changes in immune parameters during disease in patients with a CNS malignancyAML: Characterize and quantify changes in immune parameters and immunotherapeutic targets during disease in pediatric patients with…
This study has been transitioned to CTIS with ID 2024-513859-33-00 check the CTIS register for the current data. The overall objective is to assess efficacy, safety, pharmacokinetic (PK), pharmacodynamics (PD) of avalglucosidase alfa in male and…
To validate biomarkers that are associated with severe RSV infection and respiratory sequelae.
Primary objective: To obtain a detailed immunological profile of children presenting to Dutch hospitals with acute SARS-CoV-2 infection or with a SARS-CoV-2 related post-infectious inflammatory syndrome. Secondary objectives: (1) To correlate the…
The aim of this study is to describe the PK/PD characteristics of frequently used beta-lactam antibiotics in PICU patients. The main objective is to identify whether current antibiotic dosing regimens of the selected beta-lactams achieve defined…
This study has been transitioned to CTIS with ID 2024-510603-11-00 check the CTIS register for the current data. Primary Objective: To evaluate the efficacy of ION373 in improving or stabilizing gross motor function in patients with Alexander…
Our proposal builds on 12 years of sustained EU funding, a consortium covering 11 European countries and 27partners (with non-EU sites in African and two Asian populations to provide a global perspective) and our cuttingedge new research, which has…
The overall aim of the study is to gain more insight in as well as understand and map the pharmacokinetics of tacrolimus during pregnancy. Therefore, we will study tacrolimus concentrations in maternal whole blood (routine care) and via area under…
The primary objectives of this study are:- Can EEnG measure colonic motility/activity?- Can EEnG be used to distinguish between healthy subjects and patients suffering from a colonic motility disorder.Secundary objective:- What is the…
Presepsin as diagnostic marker for bacterial infection in young infants with fever of unknown origin
This study aims to evaluate the role of presepsin in the diagnosis of bacterial infections in young infants with fever of unknown origin.
The primary objective is to determine the difference in median red blood cell velocity (RBV) measured within a time interval of half an hour with dynamic light scattering technology between neonates with and without neonatal late-onset sepsis.
Our main question is: How does GDM brain immaturity affect skills that are critical for later language development? To answer this question, we will assess two skills in GDM infants and compare them to term controls in two independent (separate)…
The primary objective of the study is to assess the proportion of neonates with hyperbilirubinaemia necessitating treatment that is detected using universal TcB screening compared to using only visual inspection, while decreasing the number of heel…