791 results
This study has been transitioned to CTIS with ID 2023-503679-12-00 check the CTIS register for the current data. Part 1 (Dose Escalation) - to identify the recommended Phase 2 dose(s) and schedule(s) to be safe for JNJ-79635322. Part 2 (Dose…
The primary aim of the UPLAN-I trial is to evaluate feasibility and safety of upfront resection of large volume or cavitating tumors in the lung (including a hilar and/or mediastinal lymph node dissection if deemed possible by the treating surgeon…
This study has been transitioned to CTIS with ID 2023-510317-26-00 check the CTIS register for the current data. To evaluate the efficacy of PTC857 in reducing disease progression in subjects with amyotrophic lateral sclerosis (ALS)
This study has been transitioned to CTIS with ID 2023-506361-56-00 check the CTIS register for the current data. This study is designed to assess the efficacy and safety of pembrolizumab monotherapy compared with SoC platinum doublet chemotherapy…
The device, the cardiac arrhythmia software, is intended to record, store and analyze the heart rate data collected by a PPG sensor to provide the user with notifications of events that indicate an irregular heart rhythm. The information is not…
Objective: Is proactive integrated care costeffective and does it result in better patients experience than usual care after 12 months for patients with problems on multiple life domains?This study will focus on measuring the changes in the…
This study has been transitioned to CTIS with ID 2023-506786-63-00 check the CTIS register for the current data. Main objective:•To compare the progression-free survival of imlunestrant (Arm A) to the standard comparator of Investigator's…
To study the effect of music on sleep in surgical patients
To determine if dopaminergic dysfunction and neuroinflammation is increased in patients with TRD compared to patients who respond to antidepressant medication
This study has been transitioned to CTIS with ID 2023-509715-91-00 check the CTIS register for the current data. Primary:•To compare the effect of venglustat with standard of care Fabry therapies on left ventricular mass index over 18 months in…
Our overall aim is to study how different pathological mechanisms in cerebral SVD influence WMH shape.Primary objectiveTo study the association of a more complex WMH shape with abnormalities in small vessel morphology.Secondary objectiveTo study the…
to take a first step towards ultrahypofractionation for high-risk prostate cancer by showing the technical feasibility of PTV-margin reduction around the SV using adaptive radiotherapy. Primary: To assess the feasibility of reducing the PTV-margins…
The following questions will be addressed in the PARASOL study• Is the proposed study design feasible?,We will set up the study as a randomized pilot study to evaluate if patients are willing and able to participate in a randomized trial, i.e. are…
Primary Objective: - To investigate the effectiveness of the ProMIO lifestyle intervention (targeting protein intake and exercise behavior) on physical functioning in older adults from ethnic minorities (Turkish, Moroccan and Surinamese). Secondary…
The primary aim is to determine whether the relative aerobic load of walking is a determinant of the amount of walking in daily life in people with a chronic spinal cord injury with a walking function. Secondary goals are to gain insight into other…
The objective of this study is to analyse the longterm effectiveness of high-energy ESWT and ultrasound-guided needling in patients with symptomatic calcific tendinitis of the rotator cuff. The assessment parameters are the functional outcome, pain…
To compare free testosterone levels between male CCH patients and healthy controls Secondary Objectives: To compare differences in androstenedione, DHEA, DHT and 11oxC19 level, testosterone/estrogen ratio, activin level, inhibin level and morning…
To assess the efficacy of transcutaneous pulsed radiofrequency therapy (tPRF) as a treatment for pain in hand OA.
This study has been transitioned to CTIS with ID 2024-519351-28-00 check the CTIS register for the current data. Cross validation of the hybrid tracer ICG 99 Tc Nanoscan with respect to 99m Tc Nanoscan for the determination. In particular the…
The primary objective of the study is to assess the pharmacokinetics (PK) of PXL770 in AMN subjects at the dose of 500mg once daily (OD) and 250mg twice daily (BID) after 4 weeks of treatment.