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Precision psychiatry: Anti-inflammatory medication in Immuno-metabolic depression

This study has been transitioned to CTIS with ID 2024-513907-15-01 check the CTIS register for the current data. Among patients under treatment for depression, we will select 140 persons with IMD. In this specific group of patients, we will test…

Intraperitoneal irinotecan with concomitant FOLFOX and bevacizumab for patients with unresectable colorectal peritoneal metastases - a phase II study

This study has been transitioned to CTIS with ID 2024-517152-34-00 check the CTIS register for the current data. The primary objectives are to explore the overall survival for the addition of intraperitoneal irinotecan (75 mg) to palliative systemic…

Body surface area-based vs concentration-based dosing of cisplatin for hyperthermic intraperitoneal chemotherapy (HIPEC) in women with advanced ovarian cancer

This study has been transitioned to CTIS with ID 2024-514711-99-00 check the CTIS register for the current data. To evaluate BSA-based versus concentration-based OVHIPEC with cisplatin in patients with advanced-stage ovarian cancer.

A Randomized, Double-blind, Placebo-controlled, Multinational, Phase 3 Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects with Idiopathic Pulmonary Fibrosis (TETON-2) // A Multinational, Uncontrolled, Usability Evaluation Study of the TD-300/A Tyvaso Inhalation Device Used in RIN-PF-303

This study has been transitioned to CTIS with ID 2024-514761-19-00 check the CTIS register for the current data. The primary objective of RIN-PF-303 is to evaluate superiority of inhaled treprostinil against placebo for the annual rate of change in…

A RANDOMIZED, 2-ARM, PHASE 3 STUDY OF ELRANATAMAB (PF-06863135) VERSUS LENALIDOMIDE IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA AFTER UNDERGOING AUTOLOGOUS STEM-CELL TRANSPLANTATION

This study has been transitioned to CTIS with ID 2023-508897-27-00 check the CTIS register for the current data. Primary:• To compare the efficacy of elranatamab vs lenalidomide Secondary:- To compare the efficacy of elranatamab vs lenalidomide- To…

Indocyanine green guided identification of sentinel lymph nodes via mastectomy incision in breast cancer patients.

In this study, we aim to identify the diagnostic value of indocyanine green (ICG) fluorescence imaging for SLNBs via the mastectomy incision.

Adjuvant chemotherapy for prevention of recurrence in patients with detectable ctDNA after surgery in high-risk rectal cancer.

This study has been transitioned to CTIS with ID 2024-517700-12-00 check the CTIS register for the current data. To improve disease-free survival in patients with high-risk rectal cancer by treating these patients with adjuvant chemotherapy in case…

Global Research Initiative for Patients Screening on MASH

The primary objective of this study is to implement a transmural patient care pathway as recommended by the EASL guideline of June 2024, in order to identify patients with MASLD and its progressive form of MASH in primary care centres (PCC) and…

A PHASE 3 RANDOMIZED, OPEN-LABEL TRIAL OF SELINEXOR, POMALIDOMIDE, AND DEXAMETHASONE (SPd) VERSUS ELOTUZUMAB, POMALIDOMIDE, AND DEXAMETHASONE (EloPd) IN PATIENTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA (RRMM)

This study has been transitioned to CTIS with ID 2024-518304-53-00 check the CTIS register for the current data. The primary objective of the study is to compare the PFS of SPd versus EloPd in patients with MM who have received 1 to 4 prior anti-MM…

Recovery of physical functioning after burns

To identify potential rehabilitation needs of adult patients with burns we aim to:1) investigate the course of physical fitness, physical activity and fatigue after discharge. 2) identify factors that can predict the recovery, or lack thereof, at an…

Adagio Medical Pulsed Field Ablation (PFA) and Pulsed Field Cryoablation (PFCA) Systems for persistent Atrial Fibrillation (PsAF)

First-In-Human Clinical Investigation to evaluate the safety and performance of the Adagio Medical PFA and PFCA Systems in the ablation treatment of symptomatic Persistent Atrial Fibrillation (PsAF).