6619 results
The aim of this study is to evaluate the added benefit of integrating genetic information and state-of-the-art phenotypic information (clinical measurements) of the musculoskeletal system in groups of patients with conditions presenting with or at…
We aim to identify if pediatric PAH patients have increased plasma IL-1β and IL-18 compared to control participants, as well as increased caspase-1 cleavage and NLRP3, IL-1β and IL-18 mRNA expression in PBMCs, reflective of inflammasome activation.…
Therapeutic nadroparin administration:Primary objective: To develop evidence-based dosing regimens of nadroparin for children in different age groups by means of the objectification of the PK/PD of nadroparin.Secondary objective: 1) Investigate the…
This study*s research objective is to investigate the validity of BT measurement through skin temperature and skin heat flux measurement by the Corsano CardioWatch 287-2 against invasive rectal body temperature monitoring devices in a clinical…
The objective of this study is to investigate the role of platelets in fibrosis and inflammation by examining their effects on key cellular processes. Specifically, we aim to:1. Determine whether activated platelet stimulation induces fibrosis…
In this study, we aim to improve the genetic diagnosis of patients with genetic renal tubulopathy-related disorders. We hypothesize that a higher diagnostic yield can be obtained by genetic re-screening of patients using the updated renal gene panel…
To study the feasibility of invasive exercise right heart catheterization in adult patients with repaired tetralogy of Fallot and severe PR and to study exercise parameters in volume loaded RV in repaired tetralogy of Fallot which could help to…
To identify and synthesise patient-specific neoantigen peptides from residual material of resected pancreatic cancer tissue, from the organoids established from the resected pancreatic cancer tissue (MEC-2021-0325) and from peripheral blood.
We want to identify which patients will develop arthritis with the long-term and ambitious aim of trying to prevent the development of arthritis before it occurs. As many (most) participants will not develop arthritis, we are also studying the…
The main (primary) objective is to study the influence of sex on the pharmacokinetics (PK) of metoprolol in patients after CABG with heart valve surgery and patients with a STEMI/NSTEMI who are prescribed a standard dosage of metoprolol as part of…
Primary objective: To assess the feasibility of donor screening, collection, production and storage of sufficient CB-RBC products to potentially meet the transfusion need in extremely preterm neonates.
The overall aim of the Ageinglines cohort study is to better understand the biological ageing process and its association with the onset (pre)frailty and well-being in later life and to identify targets for delaying the biological ageing process…
Primary objective:What is the incidence of an unsafe swallow situation (PAS score >= 6) after decannulation in ICU patients who had a safe swallow situation with a tracheal cannula prior to decannulation (PAS score < 6)?Secondary…
To explore whether vigorous endurance exercise (i.e., running a marathon) alters the magnitude of cardiac damage following myocardial ischemia-reperfusion injury in amateur athletes through using an ex vivo rat heart model of myocardial infarction.
Intra-arterial pressure measurements are currently the most promising tool to guide clinical decision making in patients with suspected CMI. Implementation of pressure measurements could result in major improvements in quality of life by tailoring…
To evaluate the efficacy of a new tumor-agnostic ctDNA assay, the ctDNA estimator, to detect newly developing tumors in Lynch carriers.
To determine the proportion of travelers and migrants diagnosed with chronic schistosomiasis as per each centre*s routine assessment, who have active infection at presentation (as assessed and classified by composite reference standards integrating…
The objective is to initiate a hiPSC-resource from 10 genotyped participants of the Doetinchem Cohort Study, with a characterized life course history of up to 35 years during their adult life, with the intent to deploy mechanistic and causality…
The primary objective of the study is to determine the technical feasibility of ctDNA detection in small volumes of capillary blood. This will be investigated through determining the agreement between ctDNA measurements in venous (standard blood…