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Psychosocial care after stroke: stroke specific Patient Concerns Inventory (sPCI)

To determine the content validity and clinical utility of the Dutch sPCI according to nurses with expertise in stroke care and stroke patients, respectively.

Consumer Survey Mexico

The different processing of formulas will have an effect on stool characteristics such as consistency, frequency, amount and colour.

Immune responses in a rural to urban gradient: identifying geographical footprints of the immune system to improve vaccine development

Primary Objective: * To compare the expression of Th1 and Th2 from Europeans with those of Africans living in urban, semi urban and rural areas.Secondary Objective: * To explore the functional phenotypes of Th1 and Th2 using mass cytometry cells as…

Identifying motivational alterations associated with cancer-related fatigue: a longitudinal study in testicular cancer patients

Objectives: - To identify and compare motivational behaviour in patients during different phases of cancer treatment. - To test its associations with self-reported fatigue/depression. - To determine to what extent treatment regimen, inflammation,…

MRS-based NAD+ quantification: Responsibility of a novel
MRS-based method quantifying NAD+ in vivo

The objective of this study is to validate a novel MRS-based method to quantify NAD+ by selectively suppressing the coupled α-ATP spin system, which is overlapping with the NAD+/NADH signals in vivo. For NAD+/NADH quantification to be valuable in…

A new method for bowel cleansing in patients with a history of poor bowel preparation * A multicenter feasibility study with the Pure-Vu

Objective: The aim of this study is to evaluate if an adequate level of bowel cleansing can be achieved with the Pure-Vu in patients with previous poor bowel preparation (Boston Bowel Preparation Scale [BBPS]<6).

Emotions and Dementia : a study on (automatic) recognition of emotion expressions in dementia

The primary goal of this study is to gain a better understanding of how dementia affects the multimodal expression of emotions in face, gestures, verbal and non-verbal expressions when discussing emotional laden autobiographical memories. Therefore…

Age and performance: the relation between brain structure and cognition - Part II

Main objectives: To determine the changes in structural and functional measures over a two-year time period in healthy elderly volunteers, and to determine the association between structural and functional changes.Secondary objectives: Magnitude of…

Population Receptive Field (pRF) mapping during reaching and saccades

This project aims at identifying and characterizing these maps and their properties and roles in the human brain.To this end, we will employ pRF mapping (Dumoulin and Wandell 2008) which provides a biologically plausible means to characterize the…

Registering the immune response to an influenza vaccination challenge in PTEN Hamartoma Tumour Syndrome

Primary Objective: The primary objective is to analyse the humoral and cellular immune response to influenza vaccination in PHTS individuals.• Is the immune response to seasonal influenza vaccinations impaired in PHTS?• Do characteristics in humoral…

Leukapheresis of healthy volunteer donors for T cell study and TolDC production process validations

To obtain fresh mononuclear cells from healthy volunteer donors to be used for validation of procedures for the generation of GMP-grade T cell or tolerogenic dendritic cell products for clinical application.

The impact of deep versus standard muscle relaxation on intra-operative safety during laparoscopic surgery: a multicenter strategy study

To study the effect of deep neuromuscular block compared to standard neuromuscular block on intra-operative adverse events during laparoscopic surgery using the CLASSIC score system.

The long-term consequences of vulvar lichen sclerosus in adult women who were diagnosed in childhood or adolescence

The goal of this study is to assess the repercussions of juvenile vulvar lichen sclerosus as an adult, and to improve care after the diagnosis of JVLS has been made.

Targeting the beta-2 adrenergic pathway to improve skeletal muscle glucose uptake in healthy humans

To determine if short-term treatment with the selective beta-2-adrenergic agonist clenbuterol improves glucose disposal via the mTORC2 pathway in lean, healthy male individuals with normal physical activity

Recovery after critical illness

Evaluation of the change in health-related quality of life (HRQoL) and physical and mental health of critical illness survivors.

Gait symmetry of patients with an endoprosthetic reconstruction of the knee joint after bone tumour resection.

The primary goal of this study is to describe possible causes of gait asymmetry in patients with an endoprosthetic reconstruction of the knee joint due to a bone tumour. Therefore, the assumed gait asymmetry is first verified (part A). Subsequently…

Neural correlates of odor liking in food and e-cigarette context

To determine the effects of context (food context vs. e-cigarette context), odor category (sweet vs. savory) and user group (smokers vs. non-smokers) on reward-related brain activation.

The perception of emotional expressions in social anxiety and autism

My research on the perception of expressions beyond the face shows that some standing assumptions regarding social anxiety were incorrect24 and therefore, urgently calls for a closer investigation of alternative expression modalities including full…

Perception of Indexical Cues in Adults and Children - XL

To investigate the role of talkers* voices in speech communication in NH, HI, and CI children and adult listeners, and how the perception of talker voice information relates to the processing of indexical and linguistic information among these…

Safer & More Efficient Closure of Trocar Wounds; Manual vs. Automated, a Pilot Trial

Primary objectivesTime needed for proper closure of the trocar wounds with the automated deviceSecondary objectivesDemonstrate user-friendliness of the Mediclose System